Evidence map›Paper›PMID 41282940›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Discovery of a radiation countermeasure therapeutic for intestinal injury enabled by human organ chips combined with AI.

Alican Özkan, Gwenn Merry, Joshua Piatok, Arash Naziripour, Nina LoGrande, Thomas Matthiessen, Ryan R Posey, Megan Sperry, Russel Gould, Kevin Ho and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alican ÖzkanWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.ORCID 0000-0002-3825-5899
Gwenn MerryWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Joshua PiatokWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Arash NaziripourWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Nina LoGrandeWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Thomas MatthiessenWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Ryan R PoseyWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Megan SperryWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Russel GouldWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Kevin HoWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Agathe NeukelmanceWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Ela Contreas-PantaWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Rocco RiccardiDepartment of Surgery, Massachusetts General Hospital, Boston, MA.
Liliana BordeianouDepartment of Surgery, Massachusetts General Hospital, Boston, MA.
David ChouDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
David BreaultDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Girija GoyalWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
RESEARCH TRAINING IN NEPHROLOGYT32DK007199 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLAK, MARTIN R. · 1986 to 2022
$6.0M
Organ Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5M
FDA HHS HHSF223201310079CNIBIB NIH HHS T32 EB016652NIDDK NIH HHS P30 DK034854NIDDK NIH HHS T32 DK007199
6 · The paper itself

Abstract

There is a need for better therapies for acute radiation injury (ARI) of the human intestine as current treatments offer limited efficacy. As the ileum is most sensitive to radiation in patients receiving cancer radiation therapy, we created human Organ Chip microfluidic culture models lined by primary patient-derived ileal epithelial cells interfaced with intestinal microvascular endothelium and exposed them to clinically relevant doses of γ-radiation. These Ileum Chips recapitulated key features of ARI, including cell loss, barrier dysfunction, and inflammation, as well as a therapeutic response to a probiotic formulation (VSL#3) that protects against radiation injury in patients. Use of an AI-enabled drug repurposing algorithm (NemoCAD) with transcriptomic data led to the identification of the antifungal agent miconazole as a potential radiation countermeasure drug, and its protective activity was confirmed on-chip. Combination of AI and human Organ Chip studies may offer a powerful way to repurpose drugs for novel disease applications.

Indexed as

artificial intelligencedrug discoveryhost-microbiome interactionlive biotherapeutic productOrgan-on-a-chipradiation injury

Identifiers

PMID41282940
PMCPMC12632658

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.