Not losing sight of the bigger picture of complications associated with post-polypectomy syndrome: A case report and review of literature.

backgroundPost-polypectomy syndrome (PPS) is a rare but relevant complication of endoscopic colorectal polyp removal. Although its course is usually benign, it may conceal more severe conditions. This case report presents several complications resulting from a colorectal polypectomy. CASE SUMMARY: We report the case of a 67-year-old man who presented with asthenia and abdominal discomfort after a scheduled polypectomy. The patient was initially diagnosed with PPS and managed conservatively. However, progressive clinical deterioration led to hospital admission. Imaging revealed a right-sided intra-abdominal abscess secondary to colonic perforation. The initial polyp was identified as a subepithelial lipoma. The patient underwent successful percutaneous drainage, antibiotic therapy, and recovered without the need for surgical intervention.

conclusionThis case highlights the importance of accurate endoscopic diagnosis and technique selection. PPS should not preclude the consideration of concurrent complications. Early identification and a tailored therapeutic approach can prevent major surgical procedures and improve patient outcomes.