Evidence map›Paper›PMID 41283249›Full record

ArticleMedical sciences (Basel, Switzerland)2025

Identification and Computational Analysis of

Patricia Montserrat García-Verdín, José Elías García-Ortiz, Asbiel Felipe Garibaldi-Ríos, Ingrid Patricia Dávalos-Rodríguez, Sandra Del Carmen Mendoza-Ruvalcaba, María Teresa Magaña-Torres, Luis E Figuera, Mónica Alejandra Rosales-Reynoso, Cesar de Jesús Tovar-Jácome, Guillermo Moisés Zúñiga-González and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Patricia Montserrat García-VerdínDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
José Elías García-OrtizDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-1504-1457
Asbiel Felipe Garibaldi-RíosDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0003-9788-1106
Ingrid Patricia Dávalos-RodríguezDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
Sandra Del Carmen Mendoza-RuvalcabaDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
María Teresa Magaña-TorresDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
Luis E FigueraDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6096-4579
Mónica Alejandra Rosales-ReynosoDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-0387-4996
Cesar de Jesús Tovar-JácomeDoctorado en Genética Humana, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, Mexico.
Guillermo Moisés Zúñiga-GonzálezDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-1257-4637
Belinda Claudia Gómez-MedaInstituto de Genética Humana "Dr. Enrique Corona Rivera", Departamento de Biología Moleculary Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-2774-6390
Blanca Miriam Torres-MendozaLaboratorio de Inmunodeficiencias Humanas y Retrovirus, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-2233-571X
Raquel Villegas-PachecoUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
René Gómez-CerdaUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
Julio César Cárdenas ValdezUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
Sergio Osvaldo Meza-ChavollaUnidad de Detección y Diagnóstico Clínica de Mama, Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-0843-7595
Martha Patricia Gallegos-ArreolaDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-4539-1693

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast and ovarian cancers (BC and OC) are prevalent malignancies in women globally, with germline variants in the

objectiveThe aim of this study was to identify and characterize METHODOLOGY: Genomic DNA from 140 Mexican women with BC and/or OC, selected based on clinical criteria suggestive of BRCA2 variants, was sequenced using NGS targeting BRCA2 coding regions. Functional effects were predicted with Ensembl VEP, SIFT, and PolyPhen-2. Structural impacts of missense variants were assessed using HOPE and AlphaFold models.

results

conclusion

Indexed as

BRCA2 ProteinBreast NeoplasmsOvarian NeoplasmsAdultAgedComputational BiologyFemaleGenetic Predisposition to DiseaseHumansMexicoMiddle AgedBRCA2 ProteinBRCA2 protein, humanBRCA2 geneBRCA2 pathogenic variantsbreast cancercomputational biologygenetic variationovarian cancer

Identifiers

PMID41283249
PMCPMC12641962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.