Protein Kinase Expression of the AKT/mTOR Signaling Pathway in Peripheral Mononuclear Cells of Schizophrenia Patients: A Pilot Study.

Anastasiia S Boiko, Ekaterina V Mikhalitskaya, Elena G Kornetova, Nikolay A Bokhan, Svetlana A Ivanova

Abstract read

In one paragraph

Article in NeuroSci, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

5 authors.

Anastasiia S BoikoMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, Russia.ORCID 0000-0002-2955-9057

Ekaterina V MikhalitskayaMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, Russia.ORCID 0000-0001-7085-2741

Elena G KornetovaMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, Russia.ORCID 0000-0002-5179-9727

Nikolay A BokhanMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, Russia.ORCID 0000-0002-1052-855X

Svetlana A IvanovaMental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, Russia.ORCID 0000-0001-7078-323X

Funding

Russian Science Foundation 23-75-10072

6 · The paper itself

Abstract

A comprehensive study of the contribution of dysfunction AKT/mTOR signaling to the pathogenesis of schizophrenia is needed. The aim of the study is to determine the expression of the protein kinase AKT/mTOR signaling pathway in peripheral mononuclear cells (PMCs) of patients with schizophrenia. Determination of AKT1, mTOR, p70S6K, GSK3-α, and GSK3-β in mononuclears was performed on multiplex analyzers. Statistical data processing was carried out using SPSS. The critical significance level for the differences was 0.05. The study included 58 patients with schizophrenia (F20) and 60 healthy individuals. We found an increase in the expression of AKT1 and p706SK in PM׳s of patients (

Indexed as

cell signalingprotein kinases expressionschizophrenia

Identifiers

PMID41283305

DOI10.3390/neurosci6040116

PMCPMC12641630

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LicenceCC BY

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