ArticleJournal of molecular histology2025
Histological efficacy of high-dose intravenous vitamin C infusion in severely burned patients.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe burn injuries cause increased endothelial permeability leading to systemic capillary leak and massive fluid shifts into the extravascular space. Excessive fluid resuscitation to ensure sufficient end-organ perfusion results in critical tissue oedema. The present study assessed the underlying microscopic data regarding the integrity of thin skin dermal capillary endothelial barrier and angiogenesis after high-dose vitamin C (HDVC) administration in severely burned patients at days 1, 3 and 7 postburn. Twenty severely burned patients [20% to 25% total body surface area of second deep dermal type] were enrolled in this study. Ten patients received high-dose vitamin C infusion in a dose of 10g within the first 24 h of admission (HDVC burned group) and 10 patients did not (burned group). Patients were selected from the Burn Intensive Care Unit at El-Demerdash Hospital, Ain Shams University. On the microscopic level, HDVC infusion significantly reduced inflammation as evidenced by decreased iNOS immuno-expression and inflammatory cell count, markedly improved tissue barrier function as expressed in enhanced occludin immune-reactivity, significantly decreased the mean area percentage of dermal capillaries, and promoted angiogenesis through increased immuno-expression over time in skin punch biopsies. Overall, HDVC seems promising as an adjunct therapy in burn management, but further investigation is required on clinical grounds to determine the appropriate dose for HDVC infusion and explore its long-term outcome.
Indexed as
Identifiers
41284045What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.