Evidence map›Paper›PMID 41284059›Full record

ArticleSurgery today2026

Clinical significance of the naples prognostic score in patients with colorectal liver metastases.

Hiroshi Nakanishi, Mitsuru Yanagaki, Hiroaki Shiba, Yoichi Toyama, Masashi Tsunematsu, Yoshihiro Shirai, Michinori Matsumoto, Tomohiko Taniai, Koichiro Haruki, Kenei Furukawa and 1 more

Abstract read
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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hiroshi NakanishiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Mitsuru YanagakiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. myanagaki@jikei.ac.jp.ORCID http://orcid.org/0000-0003-0664-5830
Hiroaki ShibaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yoichi ToyamaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Masashi TsunematsuDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yoshihiro ShiraiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Michinori MatsumotoDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Tomohiko TaniaiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Koichiro HarukiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Kenei FurukawaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Toru IkegamiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe prognostic outcome of the Naples prognostic score (NPS) in patients with colorectal liver metastases (CRLMs) who have undergone hepatectomy has not been investigated. The present study investigated the prognostic value of the preoperative NPS score and other systemic inflammation-related biomarkers in patients who underwent hepatectomy for CRLMs. PATIENTS AND

methodsThe subjects included 179 patients with CRLMs who underwent hepatectomy and retrospectively investigated the association of preoperative NPS with the surgical failure-free survival (SFFS), disease-free survival (DFS), and overall survival (OS) using univariate and multivariate analyses.

resultsIn this study, the cutoff NPS value was 2. In the univariate analysis, a high NPS was associated with a worse SFFS (p = 0.04) and OS (p = 0.02). The multivariate analysis showed significant and independent predictors of the OS were extrahepatic lesions (p < 0.01), serum carcinoembryonic antigen (CEA) levels (p = 0.04), and a high NPS (p = 0.04).

conclusionThe NPS can be useful in predicting long-term outcomes in patients with CRLMs after hepatectomy.

Indexed as

Colorectal NeoplasmsHepatectomyLiver NeoplasmsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoembryonic AntigenClinical RelevanceDisease-Free SurvivalFemaleHumansMaleMiddle AgedMultivariate AnalysisPrognosisBiomarkers, TumorCarcinoembryonic AntigenColorectal liver metastasisInflammation-related scoring systemsNaples prognostic score

Identifiers

PMID41284059

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.