ArticleClinical oral investigations2025
Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Evaluation of bone changes in patients born premature using mandibular indices and fractal dimension analysis on dental panoramic radiographs.Scientific reports · 2026Article
- Mandibular Cortical Thickness Predicts Skull BMD in Adolescents.Calcified tissue international · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesThe panoramic mandibular index (PMI) and mental index (MI) assessed on dental panoramic radiographs (DPRs) have been postulated as useful for the assessment of adult bone health. However, their utility in children remains to be determined. Our objective was to establish genetic determinants of the PMI/MI and to evaluate the relationship between these indices and total body less-head bone mineral density (TBLH-BMD).
methodsThis study was embedded in the Generation R Study at a mean age of 13 years. BMD was obtained from dual-energy X-ray (DXA) scans, while radiomorphometric measurements of the mandibular bone were obtained from DPRs. Genome-wide association studies (GWAS) on PMI/MI were performed. The association between PMI/MI and BMD was assessed following a combined observational and genetic analysis using a polygenic risk score (PGS).
resultsThe PMI and MI GWAS identified an association signal (p = 2.53 × 10
conclusionsOur results suggest that PMI/MI and BMD share common biological pathways, and the former may be considered as relevant markers if screening for children with impaired bone health using DPRs. CLINICAL RELEVANCE: This study demonstrates that mandibular indices measured from panoramic radiographs can help clinicians identify pediatric patients who may have reduced bone mineral density. Both traits share a shared genetic and the association is not due to confounding factors. These findings highlight the potential of panoramic radiography as a valuable tool in assessing pediatric skeletal health.
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Registered trials
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