ArticleThe Journal of clinical endocrinology and metabolism2026
The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of androgen abuse on sleep apnea in men: a prospective cohort study.Journal of endocrinological investigation · 2026Observational
- Beyond nocturnal hypercapnia: positioning obstructive sleep apnoea within a sleep-circadian-hypothalamic network.European respiratory review : an official journal of the European Respiratory Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
contextOnly a few studies have reported a correlation between severe obstructive sleep apnea syndrome (OSAS) and hypogonadism in patients with obesity, regardless of body mass index (BMI). However, longitudinal studies exploring the role of continuous positive airway pressure (CPAP) on gonadal function are scanty.
objectiveThis work aimed to investigate in men with severe/complicated obesity the role of OSAS in decreasing testosterone levels and evaluate the effects of CPAP on hormonal status.
methodsThis cross-sectional study consecutively enrolled 204 male inpatients with complicated severe obesity, without known hypogonadism. Polysomnography (or overnight oximetry during CPAP) and blood tests for inflammation and metabolic and hormonal profiles were performed. "Decompensated OSAS" was defined as an Apnea/Hypopnea Index (AHI) in newly diagnosed, or Oxygen Desaturation Index (ODI) in treated patients, above 30 events/hour. A multiple linear regression was implemented to identify the independent factors correlated with total testosterone (TT). Lastly, a longitudinal study of 14 newly diagnosed patients was performed to evaluate the effects of CPAP on TT after 3 months of treatment.
resultsA total of 127 of 204 patients showed low TT (≤10.4 nmol/L). BMI, type 2 diabetes, C-reactive protein, and decompensated OSAS were independently associated with TT (P = .039; P = .006, P = .003, and P = .014, respectively). After 3 months of CPAP therapy, TT was higher (P = .009) and ODI was associated with such improvement, independently of BMI (P = .04).
conclusionDecompensated OSAS was found to correlate with low testosterone in men with severe obesity. Moreover, CPAP therapy was shown to improve TT independently of BMI changes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.