Evidence mapPaperPMID 41285167Full record

ReviewCurrent opinion in clinical nutrition and metabolic care2026

Artificial intelligence-guided nutritional therapy in the ICU.

Dongshen Peng, Thanaphong Phongpreecha, Nima Aghaeepour

Abstract readReview
In one paragraph

Review in Current opinion in clinical nutrition and metabolic care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dongshen PengTakeoff41, Inc., Oakland.
Thanaphong PhongpreechaTakeoff41, Inc., Oakland.
Nima AghaeepourTakeoff41, Inc., Oakland.

Funding

An AI-driven total parenteral nutrition platform for cost-effective and scientifically personalized nutrition for premature newbornsR42HD115517 · TAKEOFF41, INC. · 2025 to 2025
$1.1M
NICHD NIH HHS R42 HD115517
6 · The paper itself

Abstract

purpose of reviewCritical care nutrition remains a high-stakes and error-prone domain, particularly given the complex metabolic demands and heterogeneity of ICU populations. This review explores recent progress in integrating artificial intelligence with nutritional therapy in ICUs, highlighting its evolution and potential benefits in precision-guided support, along with current implementation challenges. RECENT

findingsWidely used in adult and neonatal ICUs, parenteral nutrition faces persistent challenges including ordering errors, practice variability, and insufficient robust long-term outcome evidence. Recent advances in machine learning have demonstrated considerable potential in predicting nutrition-related complications (e.g. neonatal morbidities, cholestasis, feeding intolerances, and malnutrition), optimizing nutrient delivery through dynamic, real-time recommendations, and enhancing clinical decision-making with large language models (LLMs) that synthesize clinical guidelines and patient data into actionable insights. However, future studies must establish causal relationships between optimal parenteral nutrition and long-term outcomes while addressing confounding factors and ingredient heterogeneity. SUMMARY: Artificial intelligence-driven nutrition therapies have the potential to significantly improve the precision, safety, and personalization of ICU nutrition practices. Continued development and validation using standardized, comprehensive, longitudinal datasets, and validation in comparative clinical trials will be critical to realizing this transformative potential.

Indexed as

Artificial IntelligenceCritical CareIntensive Care UnitsNutritional SupportNutrition TherapyHumansParenteral NutritionPrecision Medicineartificial intelligencecausal inferencecritical care nutritiondecision support systemstotal parenteral nutrition

Identifiers

PMID41285167
PMCPMC12893183

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.