Evidence map›Paper›PMID 41285771›Full record

ArticleNature communications2025

Directed rescue strategy for enhanced implant osteointegration in aged rats.

Xuan Li, Xiao Jiang, Ye He, Hongwei Xiong, Qian Huang, Kun Xu, Xin-Xin Luo, Kai Li, Bailong Tao, Kangkang Zha and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Response to Kawamoto et al.EMBO reports · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xuan Li *Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.ORCID http://orcid.org/0000-0001-9354-2105
Xiao Jiang *Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Ye HeThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Hongwei XiongKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Qian HuangKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Kun XuKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Xin-Xin LuoKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Kai LiLaboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
Bailong TaoLaboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
Kangkang ZhaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.ORCID http://orcid.org/0000-0003-0421-5466
Jing WuKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Peng LiuKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China.
Kaiyong CaiKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, PR China. kaiyong_cai@cqu.edu.cn.ORCID http://orcid.org/0000-0001-9029-680X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52333011, 52021004, 21734002 and 32171327
6 · The paper itself

Abstract

The elimination of senescent cells can enhance the osteointegration of implants in elderly patients. However, achieving specific clearance of senescent cells without adversely affecting the function of normal cells remains challenging. Here we show an implant surface modification technique to achieve specific clearance of locally senescent cells by modulating their metabolism. Our method involve modifying implants with BPTES, a glutaminase 1 (GLS1) inhibitor, through π-π stacking with dopamine. This modification effectively induces intracellular acidosis in senescent mesenchymal stem cells (MSCs) through suppression of glutaminolysis. Simultaneously, poly(γ-glutamate) (PGA), modified by a layer-by-layer method, serve as a high-density carbon source coating, continuously supporting glutamine metabolism in MSCs without ammonia production. Our results show that modified implants significantly reduce the senescence level around implants and promote osteointegration in aged rats. These findings provide promising insights into the design and application of orthopedic implants for elderly patients.

Indexed as

AgingOsseointegrationProstheses and ImplantsAnimalsCellular SenescenceGlutaminaseGlutamineHumansMaleMesenchymal Stem CellsPolyglutamic AcidRatsRats, Sprague-DawleyGlutaminaseGlutaminePolyglutamic Acid

Identifiers

PMID41285771
PMCPMC12644864

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.