ArticleNature communications2025
Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Article
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Constraining inference of across-region interactions using neural activity perturbations.bioRxiv : the preprint server for biology · 2025Article
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Abstract
It remains unclear how classical models of motor cortical hierarchy align with emerging evidence of behavioral organization in motor cortex. To address this, we combined optogenetic inactivation, Neuropixels recording, and electromyography to quantify the pattern and influence of activity in the mouse analogs of forelimb premotor and primary motor cortex (RFA and CFA) during a single-forelimb reaching task and an ethologically-inspired, all-limb climbing behavior. Results revealed that RFA's dominant influence on forelimb muscles and on CFA during reaching is replaced by a dominant influence of CFA on muscles and on RFA during climbing, even when forelimb muscle activity during climbing resembles that during reaching. Short-latency influence between regions on putative excitatory and inhibitory populations in different cortical laminae also showed behavioral specificity. Simultaneous recordings in both areas during climbing revealed a loss of activity timing differences seen during reaching previously interpreted as reflective of hierarchy. These findings demonstrate that hierarchical interactions between forelimb motor cortical regions vary between behavioral contexts.
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