Evidence map›Paper›PMID 41285975›Full record

ArticleScientific reports2025

Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats.

Pallavi Shrivastava, Oluchukwu D Biose, Riya Dahal, Abdallah Jwayyed, Rukayat A Raji, Huijing Xia, Eric Lazartigues, Ifechukwude J Biose

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pallavi ShrivastavaCardiovascular Center of Excellence, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Oluchukwu D BioseTulane Center for Aging, Tulane University School of Medicine, New Orleans, LA, USA.
Riya DahalSchool of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Abdallah JwayyedCardiovascular Center of Excellence, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Rukayat A RajiSchool of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Huijing XiaCardiovascular Center of Excellence, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Eric LazartiguesCardiovascular Center of Excellence, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Ifechukwude J BioseCardiovascular Center of Excellence, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ibiose@lsuhsc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Day and night neurobehavioral tests were performed for Spontaneously Hypertensive rats (SHR) and Wistar Kyoto rats (WKY) to establish an optimal testing window. Also, blood-brain barrier (BBB) integrity in brain areas related to cognition was measured to determine strain-specific differences. Six months old male SHR and WKY were randomly divided into day (i.e., 9-11 a.m.) and nighttime (i.e., 7-9 p.m.) testing regimen. Neurobehavioral tests included: Y-maze spontaneous alternation, open field, novel object recognition (NOR), and tail suspension test (TST). BBB integrity was measured in the cortex, hippocampus and striatum. WKY showed higher recognition memory at night compared to SHR and daytime test groups. Working memory and exploratory behavior were higher for SHR at both testing times when compared to WKY. During the day and when compared to WKY, SHR showed significant depression-like behavior which was absent during the night. SHR exhibited a higher anxiety-like behavior at both testing times when compared to WKY. Immunofluorescent signal for FITC-Dextran significantly increased in brain regions of SHR compared to WKY, but BBB tight junction proteins decreased suggesting impaired BBB integrity in SHR. In sum, NOR and TST are best performed during the dark phase to observe actual baseline outcomes for SHR and WKY. Neurobehavioral outcome differences between strains are independent of BBB integrity.

Indexed as

Behavior, AnimalBlood-Brain BarrierCircadian RhythmAnimalsAnxietyBrainHypertensionMaleMaze LearningRatsRats, Inbred SHRRats, Inbred WKYBBBCognitionDiurnalHypertensionNeurobehavior

Identifiers

PMID41285975
PMCPMC12644676

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.