ReviewNpj imaging2025
Practical considerations for clinical translation of PET imaging of adoptive cell therapies.
Review in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Specific PET Imaging for Precision Management of Lung Cancer: Advances, Clinical Translation and Future Directions.Chemical & biomedical imaging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Research and development programs for adoptive cell therapies continue to expand, but few products make it to late-phase clinical trials, and even fewer receive FDA approval. Despite undergoing extensive validation before entering the trial phase, variable results may be observed in patients due to inherent differences between preclinical models and human subjects as well as heterogeneity between tumors. Moreover, the current clinical evaluation of cell therapies, including CAR-T cells, relies on limited or inconclusive approaches - usually blood sampling or tissue biopsies - lacking spatial and temporal information about their fate in the human body. Here we offer our perspective on how the application of PET imaging to track cell therapies in clinical studies could address these shortcomings and enhance our understanding of cell therapy biodistribution, patients and trial-level therapeutic success or failure, and safety considerations. We further address key challenges, from probe development to methodological, technical, and regulatory, and financial hurdles for integrating PET imaging of cell therapies into clinical studies.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.