Evidence map›Paper›PMID 41286125›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Molecular imaging of aortic fibroblast activation protein through

Bingqian Wang, Xiao Bi, Tianfeng Ma, Long Cao, Huanhuan Liu, Zeyu Cai, Ruimin Wang, Wei Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bingqian WangDepartment of Vascular and Endovascular Surgery, First Medical Center, PLA General Hospital, Beijing, 100853, China.
Xiao BiDepartment of Nuclear Medicine, First Medical Center, PLA General Hospital, Beijing, 100853, China.
Tianfeng MaDepartment of Vascular and Endovascular Surgery, First Medical Center, PLA General Hospital, Beijing, 100853, China.
Long CaoDepartment of Vascular and Endovascular Surgery, First Medical Center, PLA General Hospital, Beijing, 100853, China.
Huanhuan LiuDepartment of Nuclear Medicine, First Medical Center, PLA General Hospital, Beijing, 100853, China.
Zeyu CaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.
Ruimin WangDepartment of Nuclear Medicine, First Medical Center, PLA General Hospital, Beijing, 100853, China. wrm@yeah.net.
Wei GuoDepartment of Vascular and Endovascular Surgery, First Medical Center, PLA General Hospital, Beijing, 100853, China. guoweiplagh@sina.com.ORCID 0000-0001-6212-8390

Funding

the National Key Research and Development Program of China 2024YFC2419000the Young Scientists Fund of the National Natural Science Foundation of China 8240071
6 · The paper itself

Abstract

purposeAortic dilation represents an early pathological manifestation of aortic aneurysm formation. Due to the nonlinear nature of aortic expansion, relying solely on imaging-based diameter measurements is insufficient to fully assess the severity of pathological progression and the risk of rupture.

methodsThis was a cross-sectional study including 50 oncology patients who underwent

resultsFAPI uptake was independently associated with abdominal aortic diameter at renal artery level (β = 2.469, 95%CI 0.481-4.458, P = 0.016). No association was observed between aortic segments' FAPI uptake and calcification. Furthermore, maximum FAPI uptake (β = 2.018, 95%CI: 0.291-3.745, P = 0.023) and calcification burden (β = 0.000533, 95%CI: 0.000040-0.001025, P = 0.035) of abdominal aorta were associated with abdominal aortic diameter at renal artery level.

conclusionOur findings indicate that FAPI uptake is associated with aortic diameter and may provide preliminary insights into early aortic remodeling, suggesting its potential as a marker for future longitudinal studies.

Indexed as

AortaFibroblast Activation Protein AlphaMolecular ImagingQuinolinesVascular CalcificationAdultAgedAortic AneurysmCross-Sectional StudiesDilatation, PathologicFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyRadiopharmaceuticals68Ga-FAPIFAP protein, humanFibroblast Activation Protein AlphaQuinolinesRadiopharmaceuticals68Ga-FAPI-PET/CTAortic dilationFibroblast activation proteinMyofibroblastsVascular smooth muscle cells

Identifiers

PMID41286125
PMCPMC12920354

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.