Evidence map›Paper›PMID 41286230›Full record

SynthesisOdontology2026

Stem cells as a therapeutic frontier for advanced periodontal regeneration: a systematic review and meta-analysis.

Saketha Vallabhaneni, Naga Surya Ganesh Vankayala, Mudita Chaturvedi, P Mohan Kumar, K Nishant, Raghavendra Reddy Nagate, Shankar T Gokhale, Mohamed Fadul A Elagib, Shreyas Tikare, Tushar Vitthalrao Bhagat and 1 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saketha VallabhaneniMaster's Student at UMBC, University of Maryland at Baltimore County, Baltimore, USA.
Naga Surya Ganesh VankayalaMaster's Student at IUI, Indiana University Indianapolis, Indianapolis, USA.
Mudita ChaturvediDepartment of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, India.
P Mohan KumarDepartment of Periodontics and Implantology, Vishnu Dental College, West Godavari, Vishnupur, Bhimavaram, Andhra Pradesh, 534202, India.
K NishantDepartment of Oral and Maxillofacial Pathology, UCMS College of Dental Surgery, Bhairahawa, Nepal. drnishantop@gmail.com.ORCID http://orcid.org/0000-0002-6770-4067
Raghavendra Reddy NagateDepartment of Oral Diagnosis, Oral Biology and Periodontology, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Shankar T GokhaleDepartment of Oral Diagnosis, Oral Biology and Periodontology, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Mohamed Fadul A ElagibDepartment of Oral Diagnosis, Oral Biology and Periodontology, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Shreyas TikareDepartment of Oral Diagnosis, Oral Biology and Periodontology, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Tushar Vitthalrao BhagatProsthetics Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University Alkharj, Al-Kharj, Saudi Arabia.
Saurabh ChaturvediDepartment of Prosthetic Dentistry, College of Dentistry King Khalid University, Abha, Saudi Arabia.

Funding

Deanship of Scientific Research, King Khalid University RGP1/134/46
6 · The paper itself

Abstract

Stem cell-based therapies have emerged as promising strategies for periodontal regeneration. This review systematically evaluates the efficacy and safety of stem cell-based therapies, including periodontal ligament, dental pulp, gingival, bone marrow, and other mesenchymal stem cells for advanced periodontal regeneration. The objective was to assess regenerative outcomes of stem cells compared to conventional treatments. A comprehensive literature search was conducted across databases, including PubMed/MEDLINE, EMBASE, Cochrane CENTRAL, Scopus, and Web of Science, plus additional sources as applicable, up to 2024 December. Studies were included if they utilized stem cell-based interventions aimed at periodontal regeneration with specified outcomes and study designs (e.g., RCTs, controlled preclinical trials). Two independent reviewers screened articles. Qualitative and quantitative analysis was done and the clinical outcomes and risk of bias were interpreted. Meta-analysis was performed using standardized mean differences (SMD) and 95% confidence intervals (PROSPERO ID.: CRD420251132434.). Nine clinical studies met inclusion. Pooled analysis demonstrated significant improvements with stem cell therapies: clinical attachment level (CAL) gain of 2.02 mm, probing depth (PD) reduction of 2.71 mm, and bone fill of 46.1%. Heterogeneity was moderate across outcomes (I

Indexed as

Guided Tissue Regeneration, PeriodontalPeriodontal DiseasesPeriodontiumRegenerationStem Cell TransplantationHumansGuided tissue regenerationMesenchymal stem cellsPeriodontal regenerationPeriodonticsStem cellsTissue engineering

Identifiers

PMID41286230

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.