Evidence map›Paper›PMID 41286389›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2026

Protective Effect of Glutathione Supplementation On Mouse Ovarian Tissue Vitrification and Autologous Transplantation.

Mengxuan Jia, Rongrong Zhang, Xue Ma, Fangyuan Liu, Shubin Li, Yuzhen Ma, Liya Su, Gang Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengxuan Jia *Clinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China.ORCID 0009-0009-8805-5957
Rongrong Zhang *Clinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China.ORCID 0009-0005-8646-4088
Xue Ma *Clinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China.ORCID 0009-0007-4682-2914
Fangyuan LiuClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China.
Shubin LiDepartment of Geriatric Medical Center, Inner Mongolia People's Hospital, No. 20 Zhaowuda Road, Hohhot, 010010, Inner Mongolia, China.
Yuzhen MaCenter of Reproductive Medicine, Inner Mongolia People's Hospital, No. 20 Zhaowuda Road, Hohhot, 010010, Inner Mongolia, China.
Liya SuClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China.
Gang LiuClinical Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, 010050, Inner Mongolia, China. 20190043@immu.edu.cn.ORCID 0000-0002-5180-3765

Funding

Joint Research Fund Program for Public Hospitals 2023GLLH0013Outstanding Young Talents Cultivation Program of Grassland Elite in Inner Mongolia Q202286the Key Technology Research, Development and Transformation Projects of Inner Mongolia 2022YFSH0102the Open Fund of the Key Laboratory of the Affiliated Hospital of Inner Mongolia Medical University 2022NYFYSYS001the Zhiyuan Talents Cultivation Program of Mongolia Medical University ZY20242129
6 · The paper itself

Abstract

Ovarian tissue vitrification is a key strategy for fertility preservation, but remains hindered by oxidative damage and compromised tissue viability. This study evaluates the cytoprotective effects of glutathione (GSH) supplementation during the vitrification of mouse ovarian tissue, including autologous transplantation experiments. Mice ovaries were cryopreserved with 0, 2, 4, or 8 mM GSH, followed by comprehensive histological, biochemical, and molecular assessments, as well as autologous transplantation to assess functional recovery. GSH, particularly at 4 mM, significantly preserved follicular architecture, enhanced antioxidant enzyme activity, attenuated mitochondrial dysfunction, DNA damage, and apoptosis, and suppressed pro-inflammatory and fibrotic signaling pathways. GSH also restored angiogenic markers and improved endocrine function in ovarian grafts after autologous transplantation, as evidenced by ameliorative levels of estradiol, progesterone, anti-Müllerian hormone (AMH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). These findings support GSH as a potent adjuvant for improving ovarian tissue vitrification outcomes and warrant further translational evaluation in fertility preservation protocols.

Indexed as

CryopreservationFertility PreservationGlutathioneOvaryVitrificationAnimalsFemaleMiceTransplantation, AutologousGlutathioneAntioxidantFertility preservationFollicular integrityGlutathioneOvarian vitrificationOxidative stress

Identifiers

PMID41286389

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.