Evidence map›Paper›PMID 41286406›Full record

ArticleCommunications biology2025

A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes.

Tabitha D Manuel, Matilda J Moström, Chelsea M Crooks, Angel Davalos, Richard Barfield, Elizabeth A Scheef, Savannah Kendall, Cecily C Midkiff, Lesli M Sprehe, Macey E Trexler and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Tabitha D Manuel *Tulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Matilda J Moström *Tulane National Biomedical Research Center, Tulane University, Covington, LA, USA.ORCID http://orcid.org/0000-0001-7261-6638
Chelsea M CrooksDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Angel DavalosDuke University School of Medicine, Durham, NC, USA.
Richard BarfieldDuke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-6276-7704
Elizabeth A ScheefTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Savannah KendallTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Cecily C MidkiffTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Lesli M SpreheTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Macey E TrexlerTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Francis A BoquetTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Monica N ShroyerTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.ORCID http://orcid.org/0000-0002-6412-0592
Victoria W DannerTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.
Lara A Doyle-MeyersTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.ORCID http://orcid.org/0000-0003-0212-9548
Carolyn WeinbaumDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Anne MirzaUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Stephen LammiUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Libby MitchellDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Claire E OteroDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7127-2327
Marissa R LeeDuke Cancer Center Institute, Duke University School of Medicine, Durham, NC, USA.
Layne W RogersDuke Cancer Center Institute, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4881-5589
Joshua GranekDuke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3908-5016
Kouros OwzarDuke University School of Medicine, Durham, NC, USA.
Daniel MalouliOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.ORCID http://orcid.org/0000-0003-1287-7283
Klaus FrühOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.ORCID http://orcid.org/0000-0001-8014-3877
Timothy F KowalikUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Cliburn ChanDuke University School of Medicine, Durham, NC, USA.
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1438-4554
Robert V BlairTulane National Biomedical Research Center, Tulane University, Covington, LA, USA.ORCID http://orcid.org/0000-0001-9616-9414
Amitinder KaurTulane National Biomedical Research Center, Tulane University, Covington, LA, USA. akaur@tulane.edu.ORCID http://orcid.org/0000-0001-6609-4896

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Virology CoreP01AI129859 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sallie R. Permar · 2019 to 2026
$31.0M
Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmissionR01HD103721 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI Amitinder Kaur, Sallie R. Permar · 2022 to 2026
$3.6M
High Throughput Multicolor Flow Cytometer Cell AnalyzerS10OD026800 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KAUR, AMITINDER · 2019 to 2019
$594k
NIAID NIH HHS P01 AI129859NICHD NIH HHS R01 HD103721NIH HHS P51 OD011104NIH HHS S10 OD026800ODCDC CDC HHS S10 OD026800U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) P51OD011104
6 · The paper itself

Abstract

Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform maternal vaccine design remain elusive due to the lack of a translational animal model. Here, we characterized the outcome of primary rhesus CMV (RhCMV) infection in pregnant, immunocompetent, RhCMV-naïve rhesus macaques. RhCMV DNA was detected in amniotic fluid and/or fetal tissues in six of 12 (50% placental transmission) dams following early second trimester gestation RhCMV inoculation. Widespread tissue dissemination dominated by one of two inoculated RhCMV strains was present in one fetus (8.3% cCMV disease). RhCMV DNA detection in the amniotic fluid was associated with elevated fetal and maternal plasma TNF-alpha and reduced maternal brain-derived neurotrophic factor and IL-10 levels. Maternal RhCMV exposure during pregnancy had a broad impact on the placenta and fetus even in the absence of congenital infection, as evidenced by ubiquitous maternal-fetal interface infection, and reduced placental efficiency and small-for-gestation age fetuses compared to control pregnancies. This model provides new insights into the complexity of CMV vertical transmission and can be used to evaluate immune and viral determinants of protection against cCMV.

Indexed as

CytomegalovirusCytomegalovirus InfectionsInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousAnimalsDisease Models, AnimalFemaleMacaca mulattaPlacentaPregnancy

Identifiers

PMID41286406
PMCPMC12644875

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.