ArticleNature immunology2025
Enteric nervous system-derived VIP restrains differentiation of LGR5
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Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
–field-weighted citation impact
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Who cites it
7 citing papers in PubMed.
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- A Historical Review of Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide in Sepsis.Biology · 2026Review
- Loss of enteric BDNF-TrkB signaling and VIPergic dysfunction underlie gastrointestinal dysmotility in abioRxiv : the preprint server for biology · 2026Article
- Tuft cells feel the pain.Nature immunology · 2026Article
- Distinguishing Features of ILC2s During Type 2 Immune Responses.European journal of immunology · 2026Review
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
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Authors and funding
39 authors.
Manuel O Jakob *Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. manuel.jakob@charite.de.ORCID http://orcid.org/0000-0003-3638-3114
Nele Sterczyk *Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sotiria BoulekouDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Patrycja M ForsterDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Luisa BarlebenDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Nadra AlzainDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Katja J JarickDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5162-7266
Roksana M PirzgalskaChampalimaud Foundation, Lisbon, Portugal.
Bruno RaposoChampalimaud Foundation, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-4734-7207
Karl HanssonDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Elisabeth E L NyströmDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Aurelia GondrandDepartment of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0004-9989-4899
Miguel González-AceraDepartment of Medicine, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nuremberg (FAU), Erlangen, Germany.
Pierre S LeclèreDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1794-9461
Marlen S LapsonDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sarah PoggenseierDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0009-0001-5343-9987
Divija DeshpandeDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9166-2509
Laura VellemanDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0009-0002-7347-8067
Tilman BreiderhoffDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1676-7498
Max Felix BrunkhorstDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Anton M SchüleMolecular and Spatial Biology of Skin, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0009-0003-3094-9778
Gabriela M GuerraDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.
Pawel DurekDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-6179-0670
Mir-Farzin MashreghiDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-8015-6907
Anja A KühliPATH.Berlin-Immunpathologie für Experimentelle Modelle, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-2293-5387
Coco ChuInstitute for Immunology, Tsinghua University, Beijing, China.
Christoph SchneiderDepartment of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0452-2960
Carl WeidingerDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9948-0088
Britta SiegmundDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0055-958X
Thierry M NordmannMolecular and Spatial Biology of Skin, Max Planck Institute of Biochemistry, Martinsried, Germany.
David VoehringerDepartment of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0001-6650-0639
Jay V PatankarDepartment of Medicine, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nuremberg (FAU), Erlangen, Germany.
Christoph BeckerDepartment of Medicine, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nuremberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0002-1388-1041
George M H BirchenoughDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Henrique Veiga-FernandesChampalimaud Foundation, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-6216-1836
Francesca RonchiDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Marina KolesnichenkoDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-7366-9061
Andreas DiefenbachDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9176-9530
Christoph S N KloseDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. christoph.klose@charite.de.ORCID http://orcid.org/0000-0001-8803-2979
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 550050344
Abstract
Barrier homeostasis relies on a finely tuned interplay between the immune system, epithelial cells and commensal microbiota. Beyond these regulators, the enteric nervous system has recently emerged as a central hub coordinating intestinal immune responses, although its role in epithelial differentiation has remained largely unexplored. Here, we identify a neuroepithelial circuit in which vasoactive intestinal peptide (VIP)-positive enteric neurons act on VIPR1
Indexed as
Enteric Nervous SystemStem CellsVasoactive Intestinal PeptideAnimalsCell DifferentiationCell LineageHomeostasisImmunity, InnateIntestinal MucosaLymphocytesMiceMice, Inbred C57BLMice, KnockoutReceptors, G-Protein-CoupledLgr5 protein, mouseReceptors, G-Protein-CoupledVasoactive Intestinal Peptide
Identifiers
PMID
41286457What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.