ArticleCommunications biology2025
Alzheimer's Tau seeds-induced pathology enhances hippocampal extracellular diffusion.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Tau PET overlap index correlation with neuropathological findings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
12 authors.
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Abstract
The extracellular space (ECS) is a complex, dynamic network occupying about 20% of the brain, filled with a cerebrospinal fluid-like solution rich in extracellular matrix (ECM) molecules. ECS properties regulate molecular diffusion, potentially influencing disease-associated protein spread in neurodegenerative diseases. However, its role in tau propagation remains unexplored. Using wild-type mice injected with tau seeds purified from Alzheimer's disease brain, we applied quantum dot single-particle tracking in live tissue to examine how tau pathology and inflammation influence extracellular diffusion. We observed increased diffusion associated with tau pathology in specific hippocampal regions. Additionally, diffusion profiles differed between cell-dense and cell-sparse areas. Astrocytes showed abnormal internalisation of proteoglycans, and matrix structural components were dysregulated, suggesting a link between altered ECM dynamics and enhanced diffusion. Increased diffusion and altered ECM dynamics might facilitate the spread of tau pathology.
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Registered trials
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