Evidence map›Paper›PMID 41286554›Full record

ArticleOral diseases2026

Association Between Oral Lichen Planus and Non-Oral Cancers: A Multicentre Case-Control SIPMO Study.

Gioele Gioco, Anna Schiavelli, Alessandra Majorana, Elena Bardellini, Silvio Abati, Andrea Sardella, Francesco Spadari, Matteo Pellegrini, Dorina Lauritano, Raffaele Borgia and 53 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06449248 (Oral Lichen Planus and Systemical Oncological Comorbidities), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06449248 completednot on this map

Oral Lichen Planus and Systemical Oncological Comorbidities: Case-control Multicenter Observational Clinical Study

TypeobservationalSponsorCatholic University of the Sacred HeartRan2023 to 2023Enrolled1,517ConditionsOral Lichen PlanusArmsChecking of appropriateness of OLP diagnosis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors.

Gioele GiocoHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0002-8637-2029
Anna SchiavelliHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.
Alessandra MajoranaDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Brescia, Italy.
Elena BardelliniDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-3955-4794
Silvio AbatiClinical Unit of Oral Medicine and Pathology, Dental School, IRCCS San Raffaele Hospital and University Vita-Salute San Raffaele, Milan, Italy.
Andrea SardellaDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università Degli Studi di Milano, Milano, Italy.ORCID https://orcid.org/0000-0003-4491-4640
Francesco SpadariDepartment of Biomedical, Surgical and Dental Sciences, Maxillo-Facial and Dental Unit, Fondazione IRCCS ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Matteo PellegriniDepartment of Biomedical, Surgical and Dental Sciences, Maxillo-Facial and Dental Unit, Fondazione IRCCS ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Dorina LauritanoDepartment of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.ORCID https://orcid.org/0000-0002-3550-1812
Raffaele BorgiaDepartment of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.
Monica PenteneroOral Medicine and Oral Oncology Unit, Department of Oncology, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0003-3972-1203
Samuele SuteraOral Medicine and Oral Oncology Unit, Department of Oncology, University of Turin, Turin, Italy.
Paolo Giacomo ArduinoDepartment of Surgical Sciences, Cir-Dental School, University of Turin, Turin, Italy.
Alessio GambinoDepartment of Surgical Sciences, Cir-Dental School, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0002-0130-0799
Roberto BroccolettiDepartment of Surgical Sciences, Cir-Dental School, University of Turin, Turin, Italy.
Matteo BiasottoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Giulia OttavianiDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Lorenzo AzziDepartment of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
Alessandro D'AiutoDepartment of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
Davide Bartolomeo GissiDepartment of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-0195-7694
Andrea GabusiDepartment of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-7247-8615
Andrea SantarelliDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy.ORCID https://orcid.org/0000-0003-4218-3354
Marco MascittiDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy.
Paolo VescoviDepartment of Medicine and Surgery, University Center of Dentistry, University of Parma, Parma, Italy.
Gloria BortolottiDepartment of Medicine and Surgery, University Center of Dentistry, University of Parma, Parma, Italy.
Maddalena ManfrediDepartment of Medicine and Surgery, University Center of Dentistry, University of Parma, Parma, Italy.ORCID https://orcid.org/0000-0001-7827-806X
Marco MeletiDepartment of Medicine and Surgery, University Center of Dentistry, University of Parma, Parma, Italy.
Grazia ZinoDivision of Dermatology, Idi-IRCCS-FLMM, Rome, Italy.
Umberto RomeoDepartment of Oral and Maxillo-Facial Sciences, University of Rome "Sapienza", Rome, Italy.
Gianluca TenoreDepartment of Oral and Maxillo-Facial Sciences, University of Rome "Sapienza", Rome, Italy.
Gianfranco FaviaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Luisa LimongelliDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Massimo PetruzziDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.ORCID https://orcid.org/0000-0002-9030-3739
Francesca DimilitoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0003-4633-4893
Maria Eleonora BizzocaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giuseppina CampisiDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
Vera PanzarellaDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0001-6339-6020
Stefania LeuciDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Rosario SerpicoMultidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
Alberta LuccheseMultidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID https://orcid.org/0000-0002-2677-0869
Giuseppe ColellaMultidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
Giacomo OteriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-0941-1645
Antonia MarcianòDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Gaetano IsolaSchool of Dentistry, Department of General Surgery and Surgical-Medical Specialties, University of Catania, Catania, Italy.
Alessandro PolizziSchool of Dentistry, Department of General Surgery and Surgical-Medical Specialties, University of Catania, Catania, Italy.
Amerigo GiudiceSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-5091-6979
Elena CalabriaSchool of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Umberto MarianiDepartment of Dentistry, ASST Papa Giovanni XXIII, Bergamo, Italy.
Daniela AdamoDepartment of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy.ORCID https://orcid.org/0000-0002-3784-4229
Federica CanforaDepartment of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy.
Filippo GrazianiDepartment of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-8780-7306
Marco NisiDepartment of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-6077-6658
Michele GiulianiDentistry - IRCCS "Casa Sollievo Della Sofferenza" San Giovanni Rotondo, Foggia, Italy.
Luisa RitrovatoDentistry - IRCCS "Casa Sollievo Della Sofferenza" San Giovanni Rotondo, Foggia, Italy.
Federica De MicheliASST Cremona, "Ospedale Maggiore di Cremona", Cremona, Italy.
Cosimo RupeHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco ScillaHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0009-0000-6418-1320
Romeo PatiniHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0001-7358-8763
Massimo CordaroHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.
Michele Davide MignognaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Carlo LajoloHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.
SIPMO (Italian Society of Oral Pathology and Medicine)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis multicentre case-control study aimed to investigate the potential association between oral lichen planus (OLP) and extraoral cancers. The secondary objective included the identification of risk factors for this association.

methodsThe study was conducted between January 2023 and June 2024 and included 21 Italian Oral Medicine centres affiliated with the Italian Society of Oral Medicine (SIPMO). The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (Prot. ID 4073) and registered at clinicaltrials.gov (ID NCT06449248).

resultsIn total, 1650 participants were enrolled (550 OLP and 1100 non-OLP patients) matched for age and sex. OLP patients showed a significantly higher prevalence of extra-oral cancers (19.8%) compared to controls (12.4%) with a 1.79 OR (1.34-2.39, p < 0.05). Moreover, erosive OLP (n = 32/120, 26.7%, p < 0.01) and plaque-like variants (n = 27/114, 23.7%, p < 0.04) seem to have a slightly increased risk of extra-oral cancer.

conclusionsPatients with OLP had a higher risk of developing extraoral cancer; moreover, erosive and plaque-like forms could be considered at higher risk. Potential pathogenic mechanisms involve an interplay between chronic inflammation, immune dysregulation and carcinogenesis. Therefore, the directionality of such association remains unclear, underscoring the need for prospective studies to clarify causality and temporal dynamics.

Indexed as

Lichen Planus, OralNeoplasmsAdultAgedCase-Control StudiesFemaleHumansItalyMaleMiddle AgedPrevalenceRisk Factorscomorbidityextra‐oral cancerneoplasmoral lichen planusSIPMO

Identifiers

PMID41286554
PMCPMC13248582

What Socratic holds

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Registered trials

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