ReviewMolecular brain2025
Perineuronal nets in the developing brain: implications for neurodevelopmental disorders.
Review in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Review
- Article
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Learning heritable multimodal brain representation via contrastive learning.Research square · 2026Article
- The astrocyte clock controls circadian perineuronal net remodeling, synapse strength and learning behavior.bioRxiv : the preprint server for biology · 2026Article
- Learning heritable multimodal brain representation via contrastive learning.bioRxiv : the preprint server for biology · 2026Article
- Editorial: Sensory-driven neural circuit maturation and implications for neurodevelopmental disorders.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies. PNNs are dense extracellular matrix structures primarily found in the central nervous system, comprising a heterogeneous array of components surrounding neurons. They play a crucial role in neuronal maturation and function, particularly in synapse formation and stabilization, which impacts higher-order brain connectivity. Emerging evidence underscores the dynamic changes in PNN composition and distribution during neuronal plasticity, with PNN remodeling shown to influence social and cognitive behaviors such as learning and memory. Conversely, disruptions in PNN dynamics have been implicated in developmental brain disorders. This review aims to present recent advancements in PNN neurobiology and to integrate these findings into our understanding of the mechanisms underlying neurodevelopmental pathogenesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.