ReviewJournal of neuroinflammation2025
The brain washing system in sepsis-associated encephalopathy.
Review in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Research Advances in the Pathogenesis of Sepsis-Associated Encephalopathy.International journal of molecular sciences · 2026Review
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling.Journal of neuroinflammation · 2026Article
- Neurological Complications in Intensive Care Units: From Delirium to Long-Term Cognitive Dysfunction-A Narrative Review.Journal of clinical medicine · 2026Review
- Integration of Systemic Immune-Inflammation Index and Lactate for diagnostic and early risk stratification in pediatric sepsis.BMC infectious diseases · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sepsis-associated encephalopathy (SAE) represents a prevalent and serious complication in patients with sepsis, contributing to substantial cognitive dysfunction and persistent neurological deficits. The cerebral clearance mechanism, consisting of the glymphatic system and meningeal lymphatic vessels (MLVs), serves a pivotal function in cerebrospinal fluid (CSF) drainage and the elimination of metabolic byproducts. The study demonstrated that intraperitoneal administration of LPS (3 mg/kg) resulted in a reduction in Aβ clearance 28 h post-injection. Moreover, acute exposure to a lower dose of LPS (1 mg/kg) led to a decreased distribution of CSF around the middle cerebral artery as early as 3 h. These concurrent observations imply that compromised functionality of this clearance mechanism may contribute to cognitive impairments induced by sepsis. This review comprehensively investigates the involvement of the cerebral clearance mechanism in the pathophysiological processes of SAE, with the objective of uncovering innovative therapeutic approaches.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.