ReviewDiscoveries (Craiova, Romania)
Exploring Preeclampsia: A Comprehensive Overview.
Review in Discoveries (Craiova, Romania). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Angiogenic Imbalance Defines Multisystem Phenotypes of Preeclampsia: A Phenotype-Oriented Cohort Study.Clinics and practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia remains a significant complication of pregnancy which emerges after the 20th week mark and is identified by proteinuria and hypertension. This review explores the multifaceted nature of preeclampsia, beginning with its complex pathology involving endothelial, platelet dysfunction and the imbalance in the factors that regulate angiogenesis. Diagnosis relies on monitoring blood pressure and assessing proteinuria, supported by laboratory tests and imaging studies to detect organ involvement. Biomarkers including Soluble fms-like tyrosine kinase (sFlt-1) and placental growth factor (PlGF) play a critical role in early detection and risk stratification. The imbalance in the ratio between these two biomarkers serves as a key in diagnosing and predicting preeclampsia. Vascular homeostasis is upset by this imbalance, which results in clinical symptoms such as hypertension and urinary protein excretion. Elevated sFlt-1 and reduced PlGF in high risk pregnancies, including those with chronic hypertension, correlate with greater clinical severity and predict adverse outcomes for maternal and fetal health. Management strategies include the use of antihypertensive medicines, fetal monitoring and delivery of the fetus based on disease severity. Despite ongoing research into predictive biomarkers and preventative measures, preeclampsia remains a challenge and necessitates a multidisciplinary approach for the well-being of both the fetus and the mother. This review serves as a comprehensive resource for clinicians and healthcare workers and by consolidating current knowledge and practical approaches allows them to stay updated on the evolving role of biomarkers in improving diagnostic accuracy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.