Evidence mapPaperPMID 41287826Full record

ReviewMedComm2025

Radiation-Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy.

Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi

Abstract readReview
In one paragraph

Review in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhihe HuInstitute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical Poisoning Army Medical University Chongqing China.
Yan ChenInstitute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical Poisoning Army Medical University Chongqing China.
Shengyi YangOncology and Hematology Department People's Liberation Army of China 96110 Hospital Yinchuan China.
Shihai DiaoOncology and Hematology Department People's Liberation Army of China 96110 Hospital Yinchuan China.
Le MaInstitute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical Poisoning Army Medical University Chongqing China.
Chunmeng ShiInstitute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical Poisoning Army Medical University Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation has been wildly used in clinics for disease therapy over a century. However, the side effects associated with radiotherapy are often substantial and multifaceted, underscoring the need for effective management of radiation-induced injuries. Additionally, with the growing reliance on nuclear technology, concerns about accidental exposures have intensified. Radiation-induced biological effects represent a highly complex process that impacts multiple physiological activities within organisms. Ongoing research aims to elucidate the underlying molecular mechanisms and to develop reliable methods for radiation dose estimation-both for emergency scenarios and therapeutic applications. This review provides a systematic overview of the biological effects of ionizing radiation, covering DNA damage and repair pathways, cellular senescence, and diverse modes of cell death. It also offers an in-depth analysis of recent advances in radiation biodosimetry and the application of radiation in cancer therapy, along with insights into future research directions. By integrating mechanistic knowledge with practical applications, this review aims to support the optimization of radiation-based strategies, enhance public health preparedness, and inspire continued innovation in the field.

Indexed as

biodosimetryinflammationradiation‐induced cell deathradiation injuryradiotherapysenescence

Identifiers

PMID41287826
PMCPMC12640621

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.