Evidence map›Paper›PMID 41287917›Full record

ArticleAnnals of clinical and translational neurology2026

Reduced Muscular Carnosine in Proximal Myotonic Myopathy-A Pilot

Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen and 2 more

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In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander GussewUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.ORCID 0000-0003-2300-4883
Maryam KargaranUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.
Maik RotheUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.
Andreas DeistungUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.ORCID 0000-0002-2427-1302
Dietrich StoevesandtUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.
Walter A WohlgemuthUniversity Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany.
David StrubeUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.
Thomas KendzierskiUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.
Anna Katharina KölschUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.
Maurits Gerhard Abraham HeuschenUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.
Markus OttoUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.
Alexander MenschUniversity Clinic and Outpatient Clinic for Neurology, University Medicine Halle (Saale), Halle (Saale), Germany.ORCID 0000-0003-0089-4473

Funding

Deutsche Forschungsgemeinschaft GU 1108/4-1Deutsche Forschungsgemeinschaft INST 271/406-1 FUGG
6 · The paper itself

Abstract

objectiveMyotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias. A hallmark feature is the selective degeneration of type-II fibers, likely driven by chronic myotonia and sustained metabolic stress. In this study, proton magnetic resonance spectroscopy (

methodsSeventy participants (27 genetically confirmed PROMM patients, 43 healthy volunteers) underwent localized

resultsPROMM patients showed significantly reduced carnosine compared with healthy volunteers (-50%, 0.05 ± 0.03 vs. 0.10 ± 0.05; p = 0.0022) and markedly elevated EMCL (threefold, 150.6 ± 80.5 vs. 48.6 ± 38.4; p = 0.0007). Intracellular pH did not differ between groups. Exploratory analysis revealed a negative correlation between carnosine and EMCL (r = -0.50, p = 0.03).

interpretationThis pilot study demonstrates that

Indexed as

CarnosineMyotonic DystrophyQuadriceps MuscleAdultAgedFemaleHumansMaleMiddle AgedPilot ProjectsProton Magnetic Resonance SpectroscopyCarnosine1H‐MR spectroscopycarnosinemusclemyotonic dystrophy type 2PROMM

Identifiers

PMID41287917
PMCPMC13071095

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.