ArticleAlzheimer disease and associated disorders
Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Inflammatory alterations mediate tau-associated neurodegeneration.Brain communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveTo determine how 18kDa Translocator (TSPO) PET, which measures inflammatory alterations, is associated with domain-specific cognition in the presence and absence of elevated amyloid.
methodsThis cross-sectional study uses data collected on 46 adults aged 50 and over who underwent TSPO PET (11C-ER176 SUVR) and amyloid PET (18F-Florbetaben SUVR) as well as medical, neurological, and neuropsychological assessments. Controls (n=21) were amyloid-negative and cognitively unimpaired while individuals with Alzheimer disease or related dementias (ADRD; n=25) were cognitively impaired, regardless of amyloid positivity. Cognition was assessed using the Mini-Mental State Examination (MMSE) and domain-specific tests included in the NACC UDSv3.
resultsGreater TSPO is associated with lower performance in episodic memory, attention/processing speed, executive function, language, and visuospatial ability in amyloid-positive individuals, but restricted to episodic memory in amyloid-negative individuals.
conclusionTargeting microglia as an additional or alternative strategy for cognitive impairment in Alzheimer disease and related dementias may provide further benefits, even in amyloid-negative individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.