ArticleBiochemistry2025
Engineering and Assay of Enzymes for Expanded Genetic Alphabet Replication.
Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Use of noncanonical nucleotides for nucleic acid replication provides a critical way to understand how and why natural nucleotides were chosen by evolution and provides potential applications in biotechnology, diagnostics, therapeutics, and DNA computation. However, monitoring noncanonical nucleotide incorporation can be difficult, especially for high-throughput applications. Therefore, we have utilized a 6-letter genetic alphabet (G, A, T, C, Z, and P) for toehold-mediated DNA strand exchange assays. Toehold hybridization and branch migration were found to proceed readily through the formation of multiple consecutive non-natural base pairs between hydrogen bonding synthetic nucleotides dZ (6-amino-5-nitro-2(1
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