Evidence map›Paper›PMID 41288885›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2025

The reproducibility of handheld ERGs recorded with skin electrode and natural pupils.

Chiara Sommer, Ferhat Turgut, Amr Saad, Matthias D Becker, Mayss Al-Sheikh, C Quentin Davis, Ulrike Rahn, Mirella T S Barboni, Delia Cabrera DeBuc, Gábor Márk Somfai

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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiara SommerDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland.
Ferhat TurgutDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland.
Amr SaadDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland.
Matthias D BeckerDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland.
Mayss Al-SheikhDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland.
C Quentin DavisLKC Technologies, Germantown, MD, USA.
Ulrike RahnLKC Technologies, Germantown, MD, USA.
Mirella T S BarboniDepartment of Ophthalmology, Semmelweis University, Budapest, Hungary.
Delia Cabrera DeBucBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Gábor Márk SomfaiDepartment of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland. somfaigm@yahoo.com.ORCID http://orcid.org/0000-0001-6329-442X

Funding

São Paulo Research Foundation FAPESP grant number 2023-07925-1
6 · The paper itself

Abstract

purposeTo investigate the reproducibility of hand-held full-field electroretinogram (ERG) to determine the minimum change required in longitudinal measurements to reach statistical significance.

methodsThe study included 27 healthy volunteers, aged 45-65. Light-adapted (ISCEV standard) full-field ERGs measured with the RETeval device (LKC Technologies, Germantown, MD, USA) were recorded using non-invasive skin electrodes, followed by a second examination 1-14 days later. Intersession variability of the a- and b-waves, the flicker responses (light intensity 85 Td·s, frequency 28.3 Hz) and the photopic negative response (PhNR, 38 Td·s on 380 Td blue) were assessed.

resultsThe mean standard deviations were 0.86, 0.83, 0.40 and 3.24 ms for a-wave, b-wave, flicker and PhNR peak times, respectively. Coefficient of variations (CV) were 32%, 22%, 18%, and 19.2% for the amplitudes of the a-wave, b-wave, flicker and PhNR, respectively.

conclusionWhile flicker ERGs had the smallest variability, ISCEV standard a-wave and b-wave times also had variability less than 1 ms, indicating excellent reproducibility. Amplitudes were more variable, with the a-wave amplitude having the most variability. While it depends on disease, longitudinal studies utilizing ERG timing are expected to be more likely to show statistically significant results due to low inter-session variability.

Indexed as

Clinical screeningElectroretinogramHandheld ERGLight-adapted ERGPhotopic negative responseReproducibilityRETeval

Identifiers

PMID41288885

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.