Evidence map›Paper›PMID 41289171›Full record

ArticleChemistry & biodiversity2026

Synthesis of New Pyrazolo[1,5-a]Pyrazin-4(5H)-One Derivatives and Effects on PI3K Protein Levels in A549 Lung Adenocarcinoma Cell Line.

Burak Kuzu, Ege Arzuk, Meltem Tan-Uygun

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Burak KuzuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey.ORCID https://orcid.org/0000-0002-7305-7177
Ege ArzukDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, İzmir, Turkey.ORCID https://orcid.org/0000-0002-3239-4855
Meltem Tan-UygunDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey.ORCID https://orcid.org/0000-0003-4190-6047

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 124Z267
6 · The paper itself

Abstract

Molecular targeted therapies have significantly advanced non-small cell lung cancer (NSCLC) treatment; however, acquired resistance in advanced stages remains a critical challenge. To overcome this, novel therapeutic targets or combination strategies are urgently needed. In this study, a new series of pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives (compounds 12-41) was designed and synthesized. Their antiproliferative activities were assessed in the A549 NSCLC cell line. Compounds 15, 16, 21, and 26-28 showed strong cytotoxicity, with IC

Indexed as

Antineoplastic AgentsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPyrazinesPyrazolesA549 CellsCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansLung NeoplasmsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPyrazinesPyrazolesabsorptionand toxicity (ADMET) | lung cancer | phosphoinositide 3‐kinase (PI3K) level | pyrazolopyrazinonesdistributionexcretionmetabolism

Identifiers

PMID41289171
PMCPMC13420638

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.