Evidence map›Paper›PMID 41290571›Full record

ArticleNature communications2025

Gut mucin fucosylation dictates the entry of botulinum toxin complexes.

Sho Amatsu, Takuhiro Matsumura, Chiyono Morimoto, Sunanda Keisham, Yoshiyuki Goto, Tomoko Kohda, Jun Hirabayashi, Kengo Kitadokoro, Takane Katayama, Hiroshi Kiyono and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sho Amatsu *Department of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Takuhiro Matsumura *Department of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Chiyono MorimotoDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Sunanda KeishamCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Yoshiyuki GotoDivision of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Tomoko KohdaGraduate School of Veterinary Sciences, Osaka Metropolitan University, Osaka, Japan.
Jun HirabayashiInstitute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan.
Kengo KitadokoroFaculty of Molecular Chemistry and Engineering, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan.
Takane KatayamaGraduate School of Biostudies, Kyoto University, Kyoto, Japan.
Hiroshi KiyonoChiba University Synergy Institute for Futuristic Mucosal Vaccine Research and Development (cSIMVa), Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0001-7307-4658
Hiroaki TatenoCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.ORCID http://orcid.org/0000-0003-3006-1659
Masahiko ZukaDepartment of Forensic Medicine and Pathology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Yukako FujinagaDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan. yukafuji@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-8623-1376

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
CYTOKINE RESPONSES TO H PYLORI INFECTION OR IMMUNIZATIONR01DK051677 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ERNST, PETER B · 1997 to 2006
$1.5M
Japan Agency for Medical Research and Development (AMED) 223fa627003h0001Japan Agency for Medical Research and Development (AMED) 23ae0121040h0003Japan Agency for Medical Research and Development (AMED) J22JK00035MEXT | Japan Society for the Promotion of Science (JSPS) 16K19123MEXT | Japan Society for the Promotion of Science (JSPS) 18K07107MEXT | Japan Society for the Promotion of Science (JSPS) 19K21257MEXT | Japan Society for the Promotion of Science (JSPS) 23K14517NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK051677
6 · The paper itself

Abstract

Botulinum toxins (BoNTs) produced by Clostridium botulinum are the most potent known bacterial toxins. The BoNT complex from serotype B-Okra (LPTC/B

Indexed as

Botulinum ToxinsBotulinum Toxins, Type AFucoseIntestinal MucosaMucinsAnimalsEnterocytesFemaleHemagglutininsHumansMaleMiceMice, Inbred C57BLMice, KnockoutBotulinum ToxinsBotulinum Toxins, Type AFucoseHemagglutininsMucins

Identifiers

PMID41290571
PMCPMC12647801

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.