Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Hakan Coskun *Division of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7581-3060
Yunxia Wang *Division of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1951-942X
Xinlei GaoDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8813-6329
Kaifu ChenDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. Kaifu.Chen@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-1009-4357
C Geoffrey BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. Geoff.Burns@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-5812-6621
Caroline E BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, USA. Caroline.Burns@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-1565-7489
Funding
RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Reversal of Heart Failure: Role of Vascular RecoveryR01HL148338 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2020 to 2023
$2.8M
A novel role for EZH2 in A-to-I RNA editing in prostate cancerR01CA278832 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Qi Cao, Kaifu Chen · 2024 to 2026
$2.0M
Mechanistic dissection of 22q11.2DS in zebrafishR01HL171206 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CAROLINE E BURNS · 2024 to 2026
$1.9M
Bioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8M
Cardiovascular disease in fetal alcohol spectrum disorderU01AA030185 · NIAAA · BOSTON CHILDREN'S HOSPITAL · PI CAROLINE E BURNS, C. Geoffrey Burns · 2022 to 2026
$1.7M
Role of S-nitrosylation in TransdifferentiationR01HL133254 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2018 to 2021
$1.6M
Computational epigenetics modeling of cell identity genesR01GM125632 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU · 2018 to 2021
$1.4M
NCI NIH HHS R01 CA278832NHLBI NIH HHS R01 HL133254NHLBI NIH HHS R01 HL148338NHLBI NIH HHS R01 HL171206NHLBI NIH HHS R35 HL135831NHLBI NIH HHS T32 HL007572NIAAA NIH HHS U01 AA030185NIGMS NIH HHS R01 GM125632NIGMS NIH HHS R01 GM138407U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL133254U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171206U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35HL135813U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL007572U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM125632U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM138407U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01HL148338U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) U01AA030185
6 · The paper itself
Abstract
Nkx2.5+ progenitor cells are specified in the bilateral zebrafish heart field, which contributes to multiple cardiovascular derivatives. After specification, the field physically separates into a cardiac fraction that migrates to the midline to form ventricular and atrial myocardium, a pharyngeal fraction that is sequestered in the pharyngeal arches before generating head muscles, the outflow tract, and pharyngeal arch arteries, and a lateral fraction that becomes inflow atrial and pacemaker cardiomyocytes as well as pericardium. Whether these progenitors are transcriptionally distinct and regionally organized has remained unclear. Here, we demonstrate that the heart field is composed of heterogeneous nkx2.5+ progenitor populations that are arranged according to their migratory paths and end fates. Through prospective fate mapping and mutant analyses, we define the derivatives of each subgroup. Our data provide a 3D blueprint of heart field organization, offering insights into cardiovascular development and identifying vulnerabilities contributing to congenital heart disease.
Indexed as
HeartHomeobox Protein Nkx-2.5Stem CellsZebrafishZebrafish ProteinsAnimalsBranchial RegionCell MovementGene Expression Regulation, DevelopmentalMyocardiumMyocytes, CardiacHomeobox Protein Nkx-2.5Nkx2.5 protein, zebrafishZebrafish Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
3D spatial organization of heterogeneous nkx2.5+ progenitors in the zebrafish heart field pre-patterns cardiovascular development. · full record | Socratic