Articlenpj aging2025
Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice.
Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
Senescence-associated frailty and sarcopenia are global challenges. We here investigated neuronal activity and skeletal muscle biology in senescence-accelerated mouse prone 8 (SAMP8) mice with scalp acupuncture stimulation (SAPS). Excise activity was assessed using rotarod test in the three groups: SAMP8 mice receiving SAPS (SP8-Ap), SAMP8 controls (SP8-C), and senescence-accelerated mouse resistant 1 controls (SR1). SP8-Ap exhibited significantly improved exercise activity compared to SP8-C. SAPS increased brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the frontal cortex of SP8-Ap. Monocyte/macrophage infiltration was significantly reduced in the gastrocnemius of SP8-Ap mice, which was associated with reduced expression of various glycogen synthase kinase-3β (GSK3β)-mediated inflammatory genes and increased insulin-like growth factor (IGF)-1 mRNA and phosphorylated AKT. These results indicate that elevation of neurotropic factors in the frontal cortex by SAPS can improve the exercise activity and skeletal muscle status. SAPS may represent a novel therapeutic approach to improve senescence-related frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.