ReviewThe Journal of physiology2025
The role of immune responses and microbiota in adipose tissue homeostasis.
Review in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Gut Microbiome-Endocrine Axis in Obesity: Mechanisms and Therapeutics.Journal of gastroenterology and hepatology · 2026Review
- Immune signaling as a determinant of cellular identity and tissue function.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
White and brown adipose tissue form a metabolic organ that plays a crucial role in regulating body energy homeostasis. Adipose tissue is richly vascularized and innervated to respond to a variety of environmental signals. Adipose tissue also contains diverse populations of innate and adaptive immune cells. These immune cells contribute to the regulation of adipose tissue function, and adipocytes in turn signal to immune cells in response to metabolic and environmental triggers. The gut microbiota have recently emerged as an additional factor that affects adipose tissue homeostasis. This can occur either directly via metabolites and bacterial products or indirectly via its effects on immune cells. Natural, co-evolved microbiota, if encountered in early postnatal life, have been shown to confer protection against obesity in later periods of life. The complexity of these factors and interactions warrants further investigation and may ultimately provide opportunities for therapeutic interventions that prevent obesity and metabolic disease.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.