ArticleThe Lancet regional health. Western Pacific2025
Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis.
Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Early-Onset Colorectal Cancer in Australia: Environmental, Microbial, and Policy Implications.Digestive diseases (Basel, Switzerland) · 2026Review
- Trends in Early-Onset and Late-Onset Colorectal Cancer by Subtype in New York State, 1976-2022.Journal of registry management · 2025Article
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7 authors.
Funding
Abstract
Background: Early-onset bowel cancer incidence (age <50 years) has increased worldwide and is highest in Australia, but how trends vary across age, histology, and anatomical site remains unclear. We investigated appendiceal, proximal colon, distal colon, rectal, and anal cancer incidence trends by age and histology in Australia. Methods: Cancer incidence rate data were obtained from nation-wide cancer registries (1990-2020). Birth cohort-specific incidence rate ratios (IRRs) and annual percentage change were estimated using age-period-cohort modelling and joinpoint regression. Findings: Combining all malignant tumour histologies, early-onset incidence rose 5-9% annually, yielding 4072 excess cases (1·5 per 100,000 person-years; 15% appendix, 28% colon, 48% rectum, 9% anus). Trends varied by site, period, and age: appendiceal cancer rose from 1990 to 2020 in 30-49-year-olds; colorectal cancers rose from around 1990-2010 in 20-29-year-olds and from 2010 to 2020 in 30-39-year-olds; anal cancer rose from 1990 to 2009 in 40-49-year-olds. Across sites, IRRs increased with successive birth cohorts since 1960. Adenocarcinoma incidence in the 1990s versus 1950s cohort was 2-3-fold for colorectum and 7-fold for appendix. The greatest subtype-specific increases occurred for appendiceal mucinous adenocarcinoma, colorectal non-mucinous adenocarcinoma, and anal squamous cell carcinoma. Colorectal neuroendocrine neoplasms, squamous cell carcinomas, and signet ring cell carcinomas rose across early-onset and later-onset strata. Interpretation: Appendiceal, colorectal, and anal cancer incidence is rising in Australia, with variation across age and histology. These generational shifts suggest evolving risk factor profiles and early-life exposures, highlighting the need to identify drivers of this growing burden. Funding: Australian Government.
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