ArticleHealth science reports2025
Molecular Characterisation of Fungi Populations in the Chronic Wounds of Filarial Lymphedema Patients in Southern Ghana: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Lymphatic filariasis (LF) and associated chronic wounds are of public health concern worldwide. Despite the significant burden of lymphatic filariasis (LF) and its associated chronic wounds, the fungal component of the wound microbiome remains poorly understood. Previous research has primarily focused on bacterial pathogens, neglecting the potential role of fungi in wound pathogenesis and progression. A comprehensive understanding of the microbial landscape, especially the overlooked fungal component, is crucial for developing effective prevention and treatment strategies. The study aimed to molecularly characterize the fungal populations present in these wounds via Internal Transcribed Spacer (ITS) sequencing. Methods: This was a cross-sectional study, with a total of 63 individuals sampled from eight (8) LF-hyperendemic communities within the Ahanta West District in Ghana. Skin and wound swabs were collected from each participant between December 2021 and February 2022 and subjected to standard culture-based techniques. Fungal isolates were identified, and their DNA was extracted for subsequent PCR amplification of the ITS region. The sequencing was performed using the Oxford Nanopore platform. Results: Of the 63 patients sampled, fungal colonies were observed in 16 individuals (25.4% prevalence) through culture-based methods. Molecular characterisation identified 24 Twenty-four (24) distinct fungal species at different frequencies from nine different genera: Conclusions: The presence of fungal pathogens and the potential for polymicrobial infections within the LF-wound environment highlight the need for comprehensive and tailored treatment protocols. Effective wound management is essential to address these complex wounds and mitigate the development of antibiotic resistance, a growing concern in chronic wound care.
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