ArticlemedRxiv : the preprint server for health sciences2025
Association of Sex and Other Demographic Characteristics with Hemoglobin A1c in Older Adults with Type 1 Diabetes: Cross-sectional analysis of the U.S. Premier Healthcare Database.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
Objective: In type 1 diabetes, results for hemoglobin A1c (HbA1c) sex-based differences are mixed with limited data in later ages. The study objective was to determine if female sex is independently associated with higher HbA1c in the United States older adult population. Research Design and Methods: A cross-sectional analysis was performed on real world Premier Healthcare data from January 2020-December 2022 examining adults with type 1 diabetes, ages 55-75. Multivariate linear and logistic regression models were used to determine demographic variables independently associated with HbA1c. Predictor variables included age, sex, race, ethnicity, insurance payor, testing location, marital status, atherosclerotic cardiovascular disease. Results: Of 12,088 individuals with HbA1c data (52.4% women, mean age 64.7 ± 5.8 years), HbA1c was 0.13% (95% CI: [0.08, 0.18], Conclusions: In this cohort with type 1 diabetes, females experienced slightly higher HbA1c and higher odds of HbA1c above recommendations. Individuals with Black race and Medicaid insurance payor experienced clinically significantly higher HbA1c levels. Further interventions to address HbA1c disparities are needed.
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Registered trials
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