Evidence map›Paper›PMID 41292734›Full record

ArticlebioRxiv : the preprint server for biology2025

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment.

Kailiang Qiao, Qing-Lin Yang, Tuo Li, Xiongfeng Chen, Zeynep Yazgan, Yoon Jung Kim, Collin Gilbreath, Jun Yi Stanley Lim, Yipeng Xie, Xiaohui Sun and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kailiang QiaoChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6097-0338
Qing-Lin YangChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6532-5699
Tuo LiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6268-7520
Xiongfeng ChenDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7445-3673
Zeynep YazganDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0002-6902-3692
Yoon Jung KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2942-294X
Collin GilbreathChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8683-983X
Jun Yi Stanley LimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4160-7434
Yipeng XieChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7454-126X
Xiaohui SunChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8218-1885
Yang LiuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0004-0602-7439
Yiyue JiaDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0006-3906-0272
Zhijian J ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8475-8251
Huocong HuangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6345-4566
Sihan WuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8329-7492

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
eDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7M
eDyNAmiC-TEXASSWOT2CA278683 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Zhijian J Chen · 2022 to 2026
$2.4M
Novel endogenous and engineered activators of STING: from mechanisms to cancer therapyR01CA299257 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, Zhijian J Chen · 2025 to 2026
$1.3M
Function of mesothelial cells in the tumor microenvironment of pancreatic ductal adenocarcinomaR00CA252009 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, HUOCONG · 2023 to 2025
$747k
NCI NIH HHS OT2 CA278683NCI NIH HHS OT2 CA278688NCI NIH HHS P30 CA142543NCI NIH HHS R00 CA252009NCI NIH HHS R01 CA299257
6 · The paper itself

Abstract

ecDNA contributes to cancer genetic heterogeneity through random segregation during mitosis. Emerging evidence links ecDNA to immune evasion, but the mechanism remains elusive. Using genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDAC), we show that

Identifiers

PMID41292734
PMCPMC12642531

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.