ArticlebioRxiv : the preprint server for biology2025
MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome.
Sunyi Chi, Xingyu Li, Peng Wei, Xuelin Huang
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
4 authors.
Sunyi ChiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4112-2074 Xingyu LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7813-2511 Peng WeiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7758-6116 Xuelin HuangDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-1192-9336 Funding
University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KONOPLEVA, MARINA Y · 2003 to 2023
$43.7MUPR/MDACC Partnership for Excellence in Cancer Research (Luis Segarra supplement)U54CA096300 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHARON Hermes GIORDANO, Paul A Scheet · 2002 to 2026
$23.8MThe University of Texas MD Anderson Cancer Center SPORE in Hepatocellular CarcinomaP50CA217674 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YAO, JAMES C · 2019 to 2023
$11.3MComparative Modeling: Informing Breast Cancer Control Practice & PolicyU01CA152958 · NCI · GEORGETOWN UNIVERSITY · PI BERRY, DONALD A, DE KONING, HARRY J · 2010 to 2015
$7.6MProject 3: Identifying Molecular Vulnerabilities to Improve Interferon Gene Therapy in Bladder CancerP01CA296429 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Peng Wei · 2025 to 2026
$6.1MAssociation analysis of rare variants with sequencing dataR01HL116720 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAN, WEI, WEI, PENG · 2013 to 2020
$3.3MOptimizing treatment decision by accounting for longitudinal biomarker trajectories and competing risks of each individualR01CA272806 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Xuelin Huang · 2023 to 2026
$1.5MHigh-dimensional Mediation Analysis of Cardiovascular Traits with Multi-omics DataR21HL170213 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, PENG · 2024 to 2025
$243kNCI NIH HHS P01 CA296429NCI NIH HHS P50 CA100632NCI NIH HHS P50 CA217674NCI NIH HHS R01 CA272806NCI NIH HHS U01 CA152958NCI NIH HHS U54 CA096300NHLBI NIH HHS R01 HL116720NHLBI NIH HHS R21 HL170213
6 · The paper itselfAbstract
Mediation analysis is a pivotal tool for elucidating the indirect effect of an environmental factor or treatment on disease through potentially high-dimensional omics data, such as gene expression profiles. However, traditional mediation analysis methods tailored for binary outcomes often rely on the rare disease assumption in logistic regression and provide inadequate measures of total mediation effect when multiple mediators have effects in different directions. In this paper, we develop a MEdiation analysis framework in LOgistic regression for high-Dimensional mediators and a binarY outcome (MELODY). It leverages a second-moment-based measure analogous to the
Indexed as
binary outcomehigh-dimensional mediatorsmediation analysismetabolomicstotal mediation effecttranscriptomics
Identifiers
PMID41292822
PMCPMC12642310
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