ReviewFrontiers in pharmacology2025
Immunometabolic integration in therapeutic strategies for managing MASLD.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Loss of immunometabolic adaptability in MASH: gut-derived signals drive macrophage reprogramming and fibrosis.Frontiers in immunology · 2026Review
- The immunometabolic nature of MASH: framing immune cells within metabolic dysfunction.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is clinically complex. Management approaches have focused on addressing the traits of metabolic syndrome and promoting weight loss. However, current treatment options are inadequate, leaving key disease-driving factors unaddressed. Evidence suggests that immune dysregulation determines disease trajectory. Metabolic pathways shape the immune landscape, and the immune system influences metabolic homeostasis. Developing therapies that integrate metabolic correction with immune restoration is essential. We review current available strategies and discuss areas where further research is needed to design drugs and therapeutic combinations that mitigate the complex metabolic and inflammatory interactions driving obesity-associated chronic liver disease. The immunomodulatory effects of obesity-focused interventions remain poorly understood. Bariatric surgery and incretin-based therapies can reduce body fat while reprogramming the hepatic immune environment. Metabolic modulators can reduce lipotoxicity, suppress harmful cytokine networks, and promote reparative immune responses. Other strategies include blocking danger-signaling pathways, modulating chemokine axes, and using cellular therapies. The goal is to interrupt pro-inflammatory amplification cascades and preserve reparative immune cell populations, redefining therapeutic possibilities for liver diseases. Despite advancements in the field, uncertainties still exist regarding the immunometabolic integration. Ongoing clinical trials and the recent approval of two drugs for treating this condition will provide valuable real-world insights in the future about the long-term safety and effectiveness of potentially more accurate treatment approaches. Moreover, causal and clinical biomarkers are being investigated to enhance the diagnosis and management of the significant challenges associated with MASLD-related cirrhosis. Prioritizing and initiating treatment earlier are key factors for achieving successful outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.