SynthesisFrontiers in pharmacology2025
Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Symptomatic Interventions for Allergic Rhinitis Without Comorbid Asthma: A Dose-Stratified Network Meta-analysis.Clinical drug investigation · 2026Pooled it
- Intranasal Resveratrol Plus Carboxymethyl-β-Glucan: A Promising Option in Clinical Practice.Biomolecules · 2026Review
- Association of nasal irrigation with reduced nasal symptoms after radioiodine ablation in differentiated thyroid cancer: a retrospective cohort study with propensity score matching.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Allergic rhinitis (AR) is a globally prevalent disease, and nasal irrigation is one of its effective treatments. This study aims to compare the efficacy and effectiveness of different nasal irrigation treatments on AR patients' nasal symptoms and quality of life (QoL). Methods: Studies on AR patients using different nasal irrigation treatments were searched from Cochrane, Embase, Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Database, and China Biology Medicine disc (CBM) up to 29 March 2025. The quality of the included studies was independently assessed using the NIH quality evaluation tool. The primary outcomes included relevant scale scores from the Total Nasal Symptom Score (TNSS), and secondary outcomes included those from the Rhinoconjuctivitis Quality of Life Questionnaire (RQLQ). Random-effects or fixed-effects models were selected for network meta-analysis, and mean difference (MD) was calculated with a 95% credibility interval (CrI). Surface under the cumulative ranking curve (SUCRA) was employed to rank various interventions. R 4.4.1 was used for statistical analysis. Results: 23 studies involving 3,584 patients were identified. The results of the network meta-analysis showed that compared with the placebo, multiple nasal irrigating agents were more significantly efficacious and effective. In terms of alleviating nasal symptoms (a lower score indicated better effectiveness), resveratrol was the most efficacious [MD: -7.7, 95% CrI (-14.0, -1.1)] (SUCRA = 92.08%), and budesonide also showed significant efficacy and effectiveness [MD: -5.6, 95% CrI (-10.0, -0.99)] (SUCRA = 83.39%). In terms of improving QoL (a lower score indicated better efficacy), cinnamon bark was the most efficacious [MD: -1.3, 95% CrI (-1.6, -0.96)](SUCRA = 95.78%). In addition, hydrogen-rich water [MD: -1.2, 95% CrI (-2.4, 0.10)](SUCRA = 82.58%) and fluticasone [MD: -0.83, 95% CrI (-0.94, -0.71)](SUCRA = 81.49%) also showed significant differences from the placebo. Conclusion: Resveratrol is the most efficacious in relieving nasal discomfort, and cinnamon bark performs best in optimizing QoL. The results of this study provide scientific evidence for the use of botanical drugs (such as resveratrol and cinnamon) in nasal irrigation for the treatment of AR, offering new options for this disease. This is conducive to promoting the application and verification of some traditional drugs within the framework of modern medicine. Systematic Review Registration: identifier CRD 420251054166.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.