ArticleFrontiers in pharmacology2025
A novel drug that reduces pneumococcal toxicity by targeting pneumolysin (PLY): efficacy of the traditional Chinese medicine
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: While existing virulence-targeting strategies predominantly rely on single-component inhibitors that exert evolutionary pressure, this study pioneers an innovative approach using the multicomponent traditional Chinese medicine Methods: Using a murine pneumococcal infection model, we evaluated the therapeutic effects of RPA on lung inflammation. Hemolysis assays and A549 cell viability tests were performed to assess PLY inhibition. Western blotting was used to characterize the PLY oligomerization dynamics following RPA treatment. Bacterial growth curves confirmed the nonantibacterial nature of RPA. Results: RPA significantly reduced pulmonary inflammation (p < 0.05) and the levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) without altering Conclusion: This study provides the first evidence that a multicomponent TCM achieves targeted antivirulence effects by blocking PLY oligomerization, providing a resistance-proof therapeutic strategy. Our findings bridge the "body-strengthening and evil-eliminating" principle of TCM with molecular pathogenesis, highlighting the potential of RPA as a novel antivirulence agent for pneumococcal infections.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.