Evidence mapPaperPMID 41293740Full record

ArticleFrontiers in endocrinology2025

Relationship between Helicobacter Pylori infection and metabolic syndrome components in adults.

Yan-Fei Jiang, Long Zhong, Jing-Jing Guo, Qiao-Fen Wang, Jia-Xu Gu, Jia-Yu Huang, Yan-Jing Liu, Yuan Lin, Dong-Hui Lu, Xiao-Fen Lian

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan-Fei JiangDepartment of General Surgery, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Long ZhongShenzhen University Medical School, Shenzhen University, Shenzhen, China.
Jing-Jing GuoDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Qiao-Fen WangDepartment of Rheumatology and Immunology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China.
Jia-Xu GuDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
Jia-Yu HuangDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Yan-Jing LiuDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Yuan LinDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Dong-Hui LuDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Xiao-Fen LianDepartment of Endocrinology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Helicobacter pylori (H. pylori, HP) infection plays a significant role in the development and progression of various intra-gastric and extra-gastric diseases. Its infection is associated with numerous factors, including a series of metabolic-related diseases, and the potential connections between them remain highly controversial. Meanwhile, the prevalence of metabolic diseases has been increasing exponentially with changes in economic levels and lifestyles. Exploring the correlations and potential mechanisms between HP and metabolic diseases is crucial for future disease prevention and control. Due to the ongoing controversy surrounding its relevance and the absence of articles investigating the metabolic-related mediating mechanisms and threshold effects of related metabolic diseases leading to HP infection, this study holds significant importance for guiding future lifestyle and disease control. Methods: By collecting relevant test and examination indicators from 7,387 participants at Peking University Shenzhen Hospital, we analyzed the potential pathogenic mechanisms using statistical methods such as regression analysis, mediation analysis, and threshold analysis. Results: We found that factors such as blood glucose levels (fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c)), Body Mass Index (BMI), and blood pressure (Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP)) were the main risk factors influencing the target outcomes in this study, while higher levels of Albumin (Alb) may have a certain protective effect, with BMI playing a particularly significant role among these factors. Conclusion: This discovery has deepened our understanding of metabolic diseases, BMI, related metabolic indicators, and HP infection.

Indexed as

Helicobacter InfectionsHelicobacter pyloriMetabolic SyndromeAdultAgedBlood GlucoseBlood PressureBody Mass IndexFemaleGlycated HemoglobinHumansMaleMiddle AgedRisk FactorsBlood GlucoseGlycated HemoglobindiabetesHbA1cHelicobacter pyloriinflammatory factorsmetabolic syndrome componentobesity

Identifiers

PMID41293740
PMCPMC12640847

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.