ArticleJournal of the American Heart Association2025
Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundResidence at high altitudes (HAs) may increase cardiovascular risk due to hypobaric hypoxia, but its synergy with pulmonary hypertension cause is unclear. This study compared clinical profile and biventricular remodeling in patients with pulmonary hypertension at HA and low altitude, and explored associate risk factors.
methodsA total of 137 patients with pulmonary hypertension who underwent cardiovascular magnetic resonance imaging were categorized into the HA (altitude ≥2500 m) and low altitude groups based on their zip code. Multiple linear regression was used to identify risk factors for ventricular remodeling.
resultsThe HA group showed higher hemoglobin, liver enzyme, and γ-glutamyl transpeptidase levels. Accordingly, the left ventricular ejection fraction in the HA group was reduced (50.91±10.13% versus 58.10±7.84%,
conclusionsHA residence was linked to more severe biventricular remodeling in patients with pulmonary hypertension, particularly in the left ventricle. Higher γ-glutamyl transpeptidase levels were independently associated with biventricular remodeling parameters.
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