Evidence map›Paper›PMID 41294237›Full record

ArticleMolecular pain

Evodiamine attenuates chemotherapy-induced peripheral neuropathy by mediating macrophage M2 polarization and inhibiting the upregulation of the p38 MAPK-TRPV1 axis in rat dorsal root ganglia.

Peipei Wu, Yong Chen, Kequn Xu, Qiangqiang Zhou, Zhourui Li, Rong Yang, Qiang Jiang

Abstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peipei WuDepartment of Pain Management, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0007-3827-2457
Yong ChenDepartment of Pain Management, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0001-0934-1667
Kequn XuDepartment of Oncology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0003-5471-1828
Qiangqiang ZhouDepartment of Anesthesiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0000-0002-8330-0986
Zhourui LiDepartment of Anesthesiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0005-5418-8162
Rong YangDepartment of Pain Management, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0004-2121-7687
Qiang JiangDepartment of Anesthesiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.ORCID 0009-0005-1569-4214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate evodiamine's analgesic effects and molecular mechanisms on chemotherapy-induced peripheral neuropathy (CIPN), focusing on the p38/MAPK-TRPV1 signaling axis and macrophage polarization in dorsal root ganglia (DRG).

methodsA paclitaxel-induced CIPN rat model was established with behavioral assessments via von Frey and thermal hyperalgesia tests. TRPV1, TRPV4, and inflammatory cytokine expression were analyzed using qRT-PCR, ELISA, and Western blot. Macrophage infiltration and polarization were evaluated by flow cytometry and immunofluorescence. Mechanistic studies utilized macrophage-conditioned media from RAW264.7 cells and clodronate liposome-mediated macrophage depletion to establish causal relationships between macrophage polarization and nociceptive behavior.

resultsEvodiamine dose-dependently alleviated paclitaxel-induced mechanical and thermal allodynia both acutely and preventively. It selectively inhibited upregulation of TRPV1 without affecting TRPV4 and reduced pro-inflammatory cytokine levels (TNF-α, IL-1β, IL-6, MCP-1) in the DRG. Evodiamine significantly reduced F4/80+ macrophage infiltration and shifted macrophage polarization from a pro-inflammatory M1 phenotype (decreased MCP1, CD86) to an anti-inflammatory M2 phenotype (increased CD163, CD206). Notably, macrophage-conditioned medium experiments revealed that evodiamine indirectly modulates neuronal TRPV1 expression through macrophage-derived factors. Furthermore, evodiamine attenuated paclitaxel-induced p38 MAPK phosphorylation in DRG neurons, with selective p38 MAPK inhibition by SB203580 confirming this pathway's critical involvement in TRPV1 regulation and pain modulation.

conclusionEvodiamine alleviates CIPN through a novel neuroimmune mechanism involving M2 macrophage polarization and inhibition of the p38/MAPK-TRPV1 axis in DRG neurons. These findings establish macrophage polarization as a key therapeutic target and highlight evodiamine's potential as a natural therapeutic agent for CIPN management.

Indexed as

Cell PolarityGanglia, SpinalMacrophagesp38 Mitogen-Activated Protein KinasesPeripheral Nervous System DiseasesQuinazolinesTRPV Cation ChannelsUp-RegulationAnimalsCytokinesHyperalgesiaMaleMicePaclitaxelRatsRats, Sprague-DawleyCytokinesevodiaminep38 Mitogen-Activated Protein KinasesPaclitaxelQuinazolinesTrpv1 protein, ratTRPV Cation Channelschemotherapy-induced peripheral neuropathyEvodiaminehyperalgesiamacrophage polarizationneuropathic painp38 MAPK

Identifiers

PMID41294237
PMCPMC12743150

What Socratic holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.