Evidence mapPaperPMID 41294355Full record

Trial reportmSystems2025

Agrarian diet improves metabolic health in HIV-positive men with

John B O'Connor, Jennifer Fouquier, Charles P Neff, John D Sterrett, Tyson Marden, Suzanne Fiorillo, Janet C Siebert, Jennifer Schneider, Nichole Nusbacher, Amy T Noe and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

John B O'Connor *Department of Microbiology & Immunology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0002-1341-833X
Jennifer Fouquier *Department of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0002-0975-8235
Charles P NeffDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
John D SterrettDepartment of Integrated Physiology, University of Colorado Boulder, Boulder, Colorado, USA.ORCID 0000-0002-0931-7181
Tyson MardenDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Suzanne FiorilloDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Janet C SiebertCytoAnalytics, Denver, Colorado, USA.
Jennifer SchneiderDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Nichole NusbacherDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Amy T NoeDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Blair FennimoreDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Janine HigginsDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Thomas B CampbellDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Brent E PalmerDepartment of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.
Catherine LozuponeDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0003-4786-7202

Funding

Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$7.7M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
Gut microbiome effects on intestinal barrier function and metabolic syndrome in HIV positive men who have sex with menR01DK131581 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$691k
Colorado Biomedical Informatics Training ProgramT15LM009451 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$457k
NCATS NIH HHS UM1 TR004399NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK108366NIDDK NIH HHS R01 DK131581NIH HHS R01DK108366,R01DK131581NIH HHS T15 LM009451NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

This study aimed to assess the impact of a high-fiber/low-fat agrarian diet (AD) on inflammation and metabolic outcomes in HIV-positive men who have sex with men (MSM). Since the gut microbiomes of MSM resemble those of individuals in agrarian cultures, including being IMPORTANCE: Our findings suggest tailoring diet interventions to baseline microbiome types can promote metabolic health in

Indexed as

Gastrointestinal MicrobiomeHIV InfectionsPrevotellaAdultFecesHomosexuality, MaleHumansMaleMiddle Ageddietgut microbiomehuman immunodeficiency virusinflammationmetabolic syndromemetagenomics

Identifiers

PMID41294355
PMCPMC12710365

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.