Evidence map›Paper›PMID 41294680›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

A Multicenter Retrospective Study of Avelumab First-Line Maintenance and Subsequent Therapies for Locally Advanced and Metastatic Urothelial Carcinoma: Subgroup Analysis of First-Line Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, and Gemcitabine Plus Cisplatin in the Japan AVElumab MAintenance and Continuous Treatment Study (JAVEMACS).

Masaomi Ikeda, Kiyohide Fujimoto, Noriyoshi Miura, Rikiya Taoka, Kiyoaki Nishihara, Daiki Ikarashi, Sei Naito, Fumitaka Shimizu, Atsuko Fujihara, Michihiro Shono and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masaomi IkedaDepartment of Urology, School of Medicine, Kitasato University, Sagamihara 252-0374, Japan.ORCID 0000-0003-1017-9799
Kiyohide FujimotoDepartment of Urology, Nara Medical University, Kashihara 634-8521, Japan.ORCID 0000-0003-1507-2464
Noriyoshi MiuraDepartment of Urology, Graduate School of Medicine, Ehime University, Toon 791-0295, Japan.ORCID 0000-0002-2229-0948
Rikiya TaokaDepartment of Urology, Faculty of Medicine, Kagawa University, Takamatsu 760-8521, Japan.
Kiyoaki NishiharaDepartment of Urology, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-1298-3273
Daiki IkarashiDepartment of Urology, School of Medicine, Iwate Medical University, Yahaba 028-3694, Japan.
Sei NaitoDepartment of Urology, Faculty of Medicine, Yamagata University, Yamagata 990-9585, Japan.ORCID 0000-0002-6104-4344
Fumitaka ShimizuDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.ORCID 0000-0002-4608-7645
Atsuko FujiharaDepartment of Urology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Michihiro ShonoMedical Department, Merck Biopharma Co., Ltd. (An Affiliate of Merck KGaA, Darmstadt, Germany), Tokyo 106-0041, Japan.
Tohru NakagawaDepartment of Urology, School of Medicine, Teikyo University, Tokyo 173-8605, Japan.ORCID 0000-0003-4041-7241
Eiji KikuchiDepartment of Urology, School of Medicine, St. Marianna University, Kawasaki 216-8511, Japan.ORCID 0000-0002-1624-6676

Funding

Merck Biopharma Co., Ltd. Japan an affiliate of Merck KGaA, Darmstadt, Germany 10.13039/100009945
6 · The paper itself

Abstract

Avelumab maintenance therapy is approved in Japan for patients with aUC without progression after PBC. This report presents subgroup analysis data from the JAVEMACS chart review of avelumab maintenance in patients who received 1L ddMVAC and GC. This retrospective study reviewed medical charts of patients with aUC (February 2021-December 2023). Overall, 350 patients (ddMVAC,

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Transitional CellAgedAged, 80 and overCisplatinDeoxycytidineDoxorubicinFemaleGemcitabineHumansJapanMaleMethotrexateMiddle AgedRetrospective StudiesAntibodies, Monoclonal, HumanizedavelumabCisplatinDeoxycytidineDoxorubicinGemcitabineMethotrexateVinblastineavelumabddMVACenfortumab vedotinGCtreatment patternsurothelial carcinoma

Identifiers

PMID41294680
PMCPMC12651103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.