Evidence map›Paper›PMID 41294682›Full record

Observational studyCurrent oncology (Toronto, Ont.)2025

Serum miRNA Signatures in Cancer Cachexia Depend on Systemic Inflammation.

Terese Louise Schmidberger Karlsen, Robin Mjelle, Ola Magne Vagnildhaug, Trude Rakel Balstad, Are Korsnes Kristensen, Jens Erik Slagsvold, Ganna S Westwik, Hege Elvebakken, Eva Hofsli, Ingunn Hatlevoll and 1 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Terese Louise Schmidberger KarlsenCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.
Robin MjelleDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Ola Magne VagnildhaugCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.ORCID 0000-0001-9419-5969
Trude Rakel BalstadCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.ORCID 0000-0002-5715-4268
Are Korsnes KristensenCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.
Jens Erik SlagsvoldCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.
Ganna S WestwikCancer Clinic, Levanger Hospital, Nord-Trøndelag Health Trust, 7601 Levanger, Norway.
Hege ElvebakkenDepartment of Oncology, Møre & Romsdal Hospital Trust, 6017 Ålesund, Norway.
Eva HofsliCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.
Ingunn HatlevollCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.
Tora Skeidsvoll SolheimCancer Clinic, St. Olavs Hospital, 7030 Trondheim, Norway.ORCID 0000-0002-2565-8437

Funding

The Joint Research Council at St. Olavs Hospital HF - Trondheim University Hospital and the Faculty of Medicine, Norwegian University of Science and Technology (NTNU). The Liaison Committee for Education, Research and Innovation in Central Norway (Samarbe Grant# 2020/28254 and 2020/39645
6 · The paper itself

Abstract

Cancer cachexia is a complex syndrome marked by involuntary weight and muscle loss, often driven by systemic inflammation. This multicenter, longitudinal observational study investigated circulating microRNA (miRNA) profiles in patients with unresectable locally advanced or metastatic colorectal cancer, comparing those with and without cachexia and inflammation. A total of 168 patients were categorized into four groups based on cachexia and C-reactive protein (CRP) levels. Cachexia was defined using the 2011 consensus criteria, incorporating weight loss, low BMI, and sarcopenia. Patients with both cachexia and systemic inflammation exhibited significantly distinct miRNA profiles as well as poorer overall survival (HR 2.10,

Indexed as

CachexiaColorectal NeoplasmsInflammationMicroRNAsNeoplasmsAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedMicroRNAsbiomarkerscachexiacancercolorectal cancerinflammationMiRNA

Identifiers

PMID41294682
PMCPMC12651830

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.