Evidence map›Paper›PMID 41294759›Full record

ReviewBiosensors2025

Potential-Resolved Electrochemiluminescence and Its Application in Disease Biomarker Detection.

Liangbiao Wang, Xiaojing Su, Rongrong Han, Dexin Du, Mingquan Guo

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liangbiao WangSchool of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, China.ORCID 0000-0003-4614-2736
Xiaojing SuDepartment of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China.
Rongrong HanSchool of Mechanics and Photoelectric Physics, Anhui University of Science and Technology, Huainan 232001, Anhui, China.
Dexin DuDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, Anhui, China.
Mingquan GuoSchool of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, China.ORCID 0009-0004-8152-657X

Funding

Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology 2024yjrc132Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology 2024yjrc146
6 · The paper itself

Abstract

Electrochemiluminescence (ECL) is a chemiluminescence phenomenon triggered by electrochemical reactions at the electrode surface, which has gradually become a high-sensitivity detection technology due to its low background, simple instrumentation, and high sensitivity. Therein, potential-resolved ECL refers to the generation of two or more ECL signals with distinct potentials and wavelengths during an electrochemical process. This unique capability enables simultaneous multi-signal outputs, making potential-resolved ECL particularly promising for self-calibration and multiplexed detection strategies. In this review, we focus on two critical aspects: on the one hand, the advancement of traditional ECL luminophores and potential-resolved ECL systems was reviewed, which were classified, respectively, into three categories to be introduced in detail (inorganic, organic and nanomaterial-based ECL luminophores or potential-resolved ECL of metal-organic complexes, layer-by-layer-modified electrodes, and nanomaterials). On the other hand, we summarized ECL detection strategies based on potential-resolved ECL systems and the application of these protocols in disease biomarker detection, which results in two categories (self-calibration strategies and multi-target strategies) for discussion. In this work, we aim to inspire investigators to explore novel ECL luminophores and design detection strategies with high performance, which could provide strong support for precision medicine, personalized assessment, portable medical devices, and the digital transformation of healthcare.

Indexed as

BiomarkersBiosensing TechniquesElectrochemical TechniquesLuminescent MeasurementsElectrodesHumansLuminescenceBiomarkersbiosensorselectrochemiluminescencepotential-resolved

Identifiers

PMID41294759
PMCPMC12650125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.