Evidence map›Paper›PMID 41295175›Full record

ReviewJournal of fungi (Basel, Switzerland)2025

Fungal Chitin Synthases: Structure, Function, and Regulation.

Linda Brain, Mark Bleackley, Monika S Doblin, Marilyn Anderson

Abstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Antifungal Potential ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Linda BrainDepartment of Ecological, Plant and Animal Science, La Trobe Institute for Sustainable Agriculture & Food (LISAF), AgriBio, Bundoora, VIC 3086, Australia.ORCID 0000-0001-6145-6034
Mark BleackleyDepartment of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.
Monika S DoblinDepartment of Ecological, Plant and Animal Science, La Trobe Institute for Sustainable Agriculture & Food (LISAF), AgriBio, Bundoora, VIC 3086, Australia.ORCID 0000-0002-8921-2725
Marilyn AndersonDepartment of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.

Funding

Grains Research and Development Corporation 9174916
6 · The paper itself

Abstract

Chitin is an essential polysaccharide of the fungal cell wall, critical for structural integrity, cell division and, in pathogenic fungi, virulence. As chitin is absent in both plant and mammalian systems, chitin synthases are considered attractive targets for the specific control of fungal pathogens. Yet despite decades of research, structural information on chitin synthases was lacking and inhibitors have failed to gain approval in the clinic. Current inhibitors are also ineffective against major agricultural pathogens such as

Indexed as

cell wall inhibitorsCHSfungal cell wallfungal chitin synthasespolysaccharide

Identifiers

PMID41295175
PMCPMC12653383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.