ReviewMetabolites2025
Endothelial Arginine Metabolism in Angiogenesis: Mechanistic Insights from Tissue Repair to Tumor Progression.
Review in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis, the process of forming new blood vessels from pre-existing vasculature, is essential both during development and in adulthood under physiological and pathological conditions. Therefore, understanding the molecular mechanisms that control angiogenesis has far-reaching implications in developmental biology and the treatment of human diseases. In this context, amino acid metabolism has emerged as a key driver of blood vessel formation. While the role of L-arginine (L-arg) in the cardiovascular system has been extensively described, whether L-arg could serve as a potential metabolite to target during tumor angiogenesis or be exploited to promote tissue regeneration remains unclear. Here, we will describe L-arg metabolism in the vascular context and its crosstalk with angiogenic metabolic pathways. We will also review the main findings regarding the role of L-arg in tissue regeneration and tumor progression, situating L-arg at the center of the discussion on regenerative and preventive vascular medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.